22412

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2497463..2498083 Replicon chromosome
Accession NC_009792
Organism Citrobacter koseri ATCC BAA-895

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag CKO_RS11445 Protein ID WP_002892050.1
Coordinates 2497865..2498083 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A8AJY4
Locus tag CKO_RS11440 Protein ID WP_012133514.1
Coordinates 2497463..2497837 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKO_RS11430 2492599..2493792 + 1194 WP_012133512.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CKO_RS11435 2493815..2496961 + 3147 WP_012133513.1 efflux RND transporter permease AcrB -
CKO_RS11440 2497463..2497837 + 375 WP_012133514.1 Hha toxicity modulator TomB Antitoxin
CKO_RS11445 2497865..2498083 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
CKO_RS11450 2498267..2498818 + 552 WP_012133515.1 maltose O-acetyltransferase -
CKO_RS11455 2498932..2499402 + 471 WP_024130587.1 membrane protein -
CKO_RS11460 2499480..2499620 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CKO_RS11465 2499622..2499882 - 261 WP_012133519.1 type B 50S ribosomal protein L31 -
CKO_RS11470 2500108..2501658 + 1551 WP_024130588.1 EAL domain-containing protein -
CKO_RS11475 2501698..2502051 - 354 WP_012133521.1 DUF1428 family protein -
CKO_RS11480 2502131..2502745 - 615 WP_012133522.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2497463..2505507 8044


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T22412 WP_002892050.1 NC_009792:2497865-2498083 [Citrobacter koseri ATCC BAA-895]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T22412 NC_009792:2497865-2498083 [Citrobacter koseri ATCC BAA-895]
ATGTCCGATAAACCATTAACGAAAACAGATTATTTGATGCGTTTACGACGCTGCCAGACAATAGACACGCTGGAACGTGT
AATAGAGAAAAATAAATATGAATTGTCTGACAATGAATTGGCTGTATTTTACTCAGCAGCAGATCACCGTCTTGCAGAAT
TGACGATGAATAAGCTCTACGACAAGATTCCCACCTCCGTGTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14437.27 Da        Isoelectric Point: 5.1444

>AT22412 WP_012133514.1 NC_009792:2497463-2497837 [Citrobacter koseri ATCC BAA-895]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT22412 NC_009792:2497463-2497837 [Citrobacter koseri ATCC BAA-895]
ATGGATGAGTACTCACCCAAAAGACATGATATCGCACAGCTTAAATTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAGGAAAGCAACCACGGTTGGGTTAATGACCCTACTTCGGCAATCAATCTTCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAGGACAATAAGCTGATTGCACAGATAGATGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTACGGCATTAATGCGCAGGATCTGCAAAAATGGCGAAAATCAGGAAACCGCCT
GTTTCGCTGCTTCGTCAATGCCACCAGGGCGAATCCTGTTAGCTTGTCATGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A8AJY4

References