Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4127936..4129625 Replicon chromosome
Accession NZ_CP086620
Organism Escherichia coli strain RIVM_C039205

Toxin (Protein)


Gene name mosT Uniprot ID V0Z9M0
Locus tag LN351_RS20155 Protein ID WP_000365809.1
Coordinates 4127936..4128856 (-) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag LN351_RS20160 Protein ID WP_001550661.1
Coordinates 4128843..4129625 (-) Length 261 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN351_RS20140 (4124026) 4124026..4125153 - 1128 WP_001550663.1 MFS transporter -
LN351_RS20145 (4125295) 4125295..4126353 - 1059 WP_122987197.1 alpha/beta hydrolase -
LN351_RS20150 (4126618) 4126618..4127502 + 885 WP_001119037.1 LysR family transcriptional regulator -
LN351_RS20155 (4127936) 4127936..4128856 - 921 WP_000365809.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LN351_RS20160 (4128843) 4128843..4129625 - 783 WP_001550661.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
LN351_RS20165 (4129941) 4129941..4133150 + 3210 WP_001521910.1 RNA-directed DNA polymerase -
LN351_RS20170 (4133497) 4133497..4133967 + 471 WP_000201185.1 hypothetical protein -
LN351_RS20175 (4133964) 4133964..4134066 + 103 Protein_3958 helix-turn-helix domain-containing protein -
LN351_RS20180 (4134158) 4134158..4134316 + 159 Protein_3959 integrase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 307 a.a.        Molecular weight: 34571.01 Da        Isoelectric Point: 7.2649

>T224105 WP_000365809.1 NZ_CP086620:c4128856-4127936 [Escherichia coli]
MDLRDSYARQVKLLMAALPYVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Download         Length: 921 bp

>T224105 NZ_CP119730:926242-926649 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29191.43 Da        Isoelectric Point: 8.9059

>AT224105 WP_001550661.1 NZ_CP086620:c4129625-4128843 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVKNGWLRRIAHGVYCRTGREPDWVDAVYCLQSQWEKPVRVAGLT
SLALQGHAHYTEQGKPQVWLALPAYVKLPGWFSAFEQSATFVTLYTSGLTADVTPFTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Download         Length: 783 bp

>AT224105 NZ_CP119730:925995-926261 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0Z9M0


Antitoxin

Source ID Structure

References