Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1426028..1426667 Replicon chromosome
Accession NC_009792
Organism Citrobacter koseri ATCC BAA-895

Toxin (Protein)


Gene name hicA Uniprot ID A0A381H3Z1
Locus tag CKO_RS22315 Protein ID WP_071818852.1
Coordinates 1426028..1426204 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CKO_RS06315 Protein ID WP_012132350.1
Coordinates 1426251..1426667 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKO_RS06295 1421119..1421994 + 876 WP_012132344.1 AraC family transcriptional regulator -
CKO_RS06300 1421971..1423137 - 1167 WP_012132345.1 benzoate/H(+) symporter BenE family transporter -
CKO_RS06305 1423230..1423766 + 537 WP_012132346.1 XRE family transcriptional regulator -
CKO_RS06310 1423845..1425806 + 1962 WP_012132347.1 U32 family peptidase -
CKO_RS22315 1426028..1426204 + 177 WP_071818852.1 type II toxin-antitoxin system HicA family toxin Toxin
CKO_RS06315 1426251..1426667 + 417 WP_012132350.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CKO_RS06320 1426719..1428128 + 1410 WP_012132351.1 PLP-dependent aminotransferase family protein -
CKO_RS06325 1428447..1429871 + 1425 WP_012132353.1 aminobutyraldehyde dehydrogenase -
CKO_RS22320 1429970..1430065 - 96 WP_071818853.1 stress response membrane protein YncL -
CKO_RS06330 1430257..1430430 + 174 WP_048902428.1 GhoT/OrtT family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(82-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6810.81 Da        Isoelectric Point: 10.8122

>T22410 WP_071818852.1 NC_009792:1426028-1426204 [Citrobacter koseri ATCC BAA-895]
VKQSEFRRWLESQGVDVTNGTNHLKLRYHDKRSVMPRHPGDEIKDTLRKAILKQLGLN

Download         Length: 177 bp

>T22410 NC_009792:1426028-1426204 [Citrobacter koseri ATCC BAA-895]
GTGAAGCAGAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCATGACAAACGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCTTGGTTTGAATTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15342.61 Da        Isoelectric Point: 4.4377

>AT22410 WP_012132350.1 NC_009792:1426251-1426667 [Citrobacter koseri ATCC BAA-895]
MRYPVNLIPAEEGGYVVSFPDIPEALTQGDTRHESLEAAQGALVTAFEFYFEDNQPIPLPSMVDEADDYVEIPLSIASKV
LLLNAFLESKITQQELARRIGRPKQEITRLFDLKHATKIDAVQIAAKALGKELSLTML

Download         Length: 417 bp

>AT22410 NC_009792:1426251-1426667 [Citrobacter koseri ATCC BAA-895]
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAGTCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGAAGCTGATGATTATGTGGAGATTCCTCTAAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTGAAACACGCAACGAAAATTGATGCTGTACAGATTGCGGCCAAAGCATTGGGTAAAGAGTTAT
CGCTGACTATGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A381H3Z1

Antitoxin

Source ID Structure

References