Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 72584..73416 Replicon chromosome
Accession NZ_CP086620
Organism Escherichia coli strain RIVM_C039205

Toxin (Protein)


Gene name yeeV Uniprot ID E3PN67
Locus tag LN351_RS00310 Protein ID WP_000854775.1
Coordinates 72584..72958 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A426P7N5
Locus tag LN351_RS00315 Protein ID WP_001285645.1
Coordinates 73048..73416 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN351_RS00280 (67948) 67948..68871 - 924 WP_000535949.1 carboxylate/amino acid/amine transporter -
LN351_RS00285 (68982) 68982..70166 - 1185 WP_001172876.1 sugar efflux transporter -
LN351_RS00290 (70571) 70571..70776 - 206 Protein_57 RhuM family protein -
LN351_RS00295 (70960) 70960..71802 - 843 WP_001274548.1 DUF4942 domain-containing protein -
LN351_RS00300 (71887) 71887..72084 - 198 WP_000772035.1 DUF957 domain-containing protein -
LN351_RS00305 (72096) 72096..72587 - 492 WP_000976825.1 DUF5983 family protein -
LN351_RS00310 (72584) 72584..72958 - 375 WP_000854775.1 TA system toxin CbtA family protein Toxin
LN351_RS00315 (73048) 73048..73416 - 369 WP_001285645.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LN351_RS00320 (73579) 73579..73800 - 222 WP_000692303.1 DUF987 domain-containing protein -
LN351_RS00325 (73869) 73869..74345 - 477 WP_001318130.1 RadC family protein -
LN351_RS00330 (74361) 74361..74846 - 486 WP_000213721.1 antirestriction protein -
LN351_RS00335 (74938) 74938..75756 - 819 WP_001175173.1 DUF932 domain-containing protein -
LN351_RS00340 (75846) 75846..76079 - 234 WP_001278284.1 DUF905 family protein -
LN351_RS00345 (76085) 76085..76762 - 678 WP_001097567.1 hypothetical protein -
LN351_RS00350 (76913) 76913..77593 - 681 WP_001282911.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13965.02 Da        Isoelectric Point: 8.2830

>T224084 WP_000854775.1 NZ_CP086620:c72958-72584 [Escherichia coli]
MKTLPDTLVREASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T224084 NZ_CP119726:2189676-2189779 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13678.37 Da        Isoelectric Point: 5.4492

>AT224084 WP_001285645.1 NZ_CP086620:c73416-73048 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTNG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT224084 NZ_CP119726:c2189817-2189546 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E3PN67

Antitoxin

Source ID Structure
AlphaFold DB A0A426P7N5

References