Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2817020..2817658 Replicon chromosome
Accession NZ_CP086618
Organism Escherichia coli strain RIVM_C039227

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag LN355_RS13750 Protein ID WP_000813795.1
Coordinates 2817482..2817658 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LN355_RS13745 Protein ID WP_076797675.1
Coordinates 2817020..2817436 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN355_RS13725 (2812172) 2812172..2813113 - 942 WP_001251315.1 ABC transporter permease -
LN355_RS13730 (2813114) 2813114..2814127 - 1014 WP_001551095.1 ABC transporter ATP-binding protein -
LN355_RS13735 (2814145) 2814145..2815290 - 1146 WP_001551094.1 ABC transporter substrate-binding protein -
LN355_RS13740 (2815535) 2815535..2816941 - 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
LN355_RS13745 (2817020) 2817020..2817436 - 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LN355_RS13750 (2817482) 2817482..2817658 - 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LN355_RS13755 (2817880) 2817880..2818110 + 231 WP_023910283.1 YncJ family protein -
LN355_RS13760 (2818202) 2818202..2820163 - 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LN355_RS13765 (2820236) 2820236..2820772 - 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
LN355_RS13770 (2820864) 2820864..2822036 + 1173 WP_001551088.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T224070 WP_000813795.1 NZ_CP086618:c2817658-2817482 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T224070 NZ_CP119675:c189371-189192 [Bacillus velezensis]
GTGCTTGAGAAAGTGGGTATAACAATTGCTTTCCTTATTCCTATCACGGTTTTAATCATCAACTGTTTAACGATAGCTGA
AAAGATTCAAAACCTGATGAAGAATAAAGAAAGCAAAAAGAAAAAGCGTACACGCAAGCGCCTCCGTAGCAAGAGACAAC
GCAAACGTATACGCAGATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT224070 WP_076797675.1 NZ_CP086618:c2817436-2817020 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT224070 NZ_CP119675:189318-189409 [Bacillus velezensis]
TAAAACCGTGATAGGAATAAGGAAAGCAATTGTTATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTATAACTC
TATTATAGCATA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References