Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4570916..4571511 Replicon chromosome
Accession NZ_CP086616
Organism Escherichia coli strain RIVM_C039629

Toxin (Protein)


Gene name chpB Uniprot ID A0A0V9NWK6
Locus tag LN353_RS22085 Protein ID WP_019842229.1
Coordinates 4570916..4571266 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag LN353_RS22090 Protein ID WP_001223213.1
Coordinates 4571260..4571511 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN353_RS22065 (4566246) 4566246..4567268 - 1023 WP_001550507.1 ABC transporter permease -
LN353_RS22070 (4567282) 4567282..4568784 - 1503 WP_001550506.1 sugar ABC transporter ATP-binding protein -
LN353_RS22075 (4568916) 4568916..4569872 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LN353_RS22080 (4570182) 4570182..4570712 + 531 WP_000055075.1 inorganic diphosphatase -
LN353_RS22085 (4570916) 4570916..4571266 - 351 WP_019842229.1 endoribonuclease toxin ChpB Toxin
LN353_RS22090 (4571260) 4571260..4571511 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LN353_RS22095 (4571723) 4571723..4572064 - 342 WP_001550504.1 gamma-glutamylcyclotransferase -
LN353_RS22100 (4572067) 4572067..4575846 - 3780 WP_001550503.1 autotransporter assembly complex protein TamB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-115)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12483.44 Da        Isoelectric Point: 5.6097

>T224045 WP_019842229.1 NZ_CP086616:c4571266-4570916 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVWMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T224045 NZ_CP119577:2031627-2031730 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT224045 WP_001223213.1 NZ_CP086616:c4571511-4571260 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT224045 NZ_CP119577:c2031768-2031497 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0V9NWK6


Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References