Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1098037..1098691 Replicon chromosome
Accession NZ_CP086616
Organism Escherichia coli strain RIVM_C039629

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag LN353_RS05395 Protein ID WP_000244781.1
Coordinates 1098284..1098691 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0V9GG32
Locus tag LN353_RS05390 Protein ID WP_001564007.1
Coordinates 1098037..1098303 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN353_RS05370 (1094125) 1094125..1095558 - 1434 WP_001564009.1 6-phospho-beta-glucosidase BglA -
LN353_RS05375 (1095603) 1095603..1095914 + 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -
LN353_RS05380 (1096078) 1096078..1096737 + 660 WP_000250274.1 hemolysin III family protein -
LN353_RS05385 (1096814) 1096814..1097794 - 981 WP_001564008.1 tRNA-modifying protein YgfZ -
LN353_RS05390 (1098037) 1098037..1098303 + 267 WP_001564007.1 FAD assembly factor SdhE Antitoxin
LN353_RS05395 (1098284) 1098284..1098691 + 408 WP_000244781.1 protein YgfX Toxin
LN353_RS05400 (1098731) 1098731..1099252 - 522 WP_001055874.1 flavodoxin FldB -
LN353_RS05405 (1099364) 1099364..1100260 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
LN353_RS05410 (1100285) 1100285..1100995 + 711 WP_001564005.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LN353_RS05415 (1101001) 1101001..1102734 + 1734 WP_001564004.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T224026 WP_000244781.1 NZ_CP086616:1098284-1098691 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T224026 NZ_CP119571:c1229153-1228902 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATACAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10565.15 Da        Isoelectric Point: 5.1599

>AT224026 WP_001564007.1 NZ_CP086616:1098037-1098303 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWMMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT224026 NZ_CP119571:c1228912-1228739 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0V9GG32

References