Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VagC |
Location | 3373071..3373714 | Replicon | chromosome |
Accession | NZ_CP086615 | ||
Organism | Spiribacter sp. E85 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | LMH63_RS15775 | Protein ID | WP_109678914.1 |
Coordinates | 3373313..3373714 (+) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | LMH63_RS15770 | Protein ID | WP_109678913.1 |
Coordinates | 3373071..3373307 (+) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LMH63_RS15735 (LMH63_15735) | 3368826..3369176 | - | 351 | WP_109678908.1 | hypothetical protein | - |
LMH63_RS15740 | 3369225..3369554 | - | 330 | WP_109678909.1 | DUF2589 domain-containing protein | - |
LMH63_RS15745 | 3369551..3369973 | - | 423 | WP_109678910.1 | DUF2589 domain-containing protein | - |
LMH63_RS15750 (LMH63_15745) | 3369996..3370778 | - | 783 | WP_229332802.1 | DUF4332 domain-containing protein | - |
LMH63_RS15755 (LMH63_15750) | 3370868..3371014 | + | 147 | WP_199225672.1 | hypothetical protein | - |
LMH63_RS15760 (LMH63_15755) | 3371226..3372449 | - | 1224 | WP_109678911.1 | type II toxin-antitoxin system HipA family toxin | - |
LMH63_RS15765 (LMH63_15760) | 3372442..3372759 | - | 318 | WP_109678912.1 | helix-turn-helix transcriptional regulator | - |
LMH63_RS15770 (LMH63_15765) | 3373071..3373307 | + | 237 | WP_109678913.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
LMH63_RS15775 (LMH63_15770) | 3373313..3373714 | + | 402 | WP_109678914.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LMH63_RS15780 (LMH63_15775) | 3373955..3374353 | - | 399 | WP_109678915.1 | type II toxin-antitoxin system VapC family toxin | - |
LMH63_RS15785 (LMH63_15780) | 3374350..3374580 | - | 231 | WP_109678916.1 | prevent-host-death protein | - |
LMH63_RS15790 (LMH63_15785) | 3375162..3376466 | + | 1305 | WP_109678917.1 | hypothetical protein | - |
LMH63_RS15795 (LMH63_15790) | 3376574..3376771 | - | 198 | WP_109678918.1 | DUF2283 domain-containing protein | - |
LMH63_RS15800 (LMH63_15795) | 3376768..3376973 | - | 206 | Protein_3118 | hypothetical protein | - |
LMH63_RS15805 (LMH63_15800) | 3377108..3377845 | - | 738 | WP_109678919.1 | type III pantothenate kinase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14687.92 Da Isoelectric Point: 7.2781
>T224020 WP_109678914.1 NZ_CP086615:3373313-3373714 [Spiribacter sp. E85]
VAFLLDTNTCIYIINRRPPEVFERFRGHAIGEIGISSITGAELTFGVAKSGSRRNRAALDKFLAPLDILPFDEAAMRQYG
PLRAHLEREGQPIGSMDLLIAAHALALGYTLITNNLREFARVPNLPLENWVGS
VAFLLDTNTCIYIINRRPPEVFERFRGHAIGEIGISSITGAELTFGVAKSGSRRNRAALDKFLAPLDILPFDEAAMRQYG
PLRAHLEREGQPIGSMDLLIAAHALALGYTLITNNLREFARVPNLPLENWVGS
Download Length: 402 bp
>T224020 NZ_CP119567:c625659-625228 [Pararhizobium sp. T808]
ATGATCTTGCTTGATACCAACGTGATATCGGAGCCTTGGAAACCGGCCCCTGACGAGACAGTGGTCGCCTGGCTGGACGC
GCAAGCAGTTGAGACGCTGTTTATCTCAGCGATAACAATTGCCGAACTGCGTTTTGGGATCGCCGCCATGCCCGCTGGGA
AACGGCAAACTATTCTCCGTGATCGCCTGGAGGTCGAAGTGCTTCCGCATTTTGCGGGGCGTATCCTGCCTTTTGGCGTT
GCCACGTCGCAGTTTTATTCGGAACTGATGGTGCGCGCTCGGTTGTCCGGTAAGGCGATCGGCGAGGCCGATGGATATAT
TGCAGCCACGGCAGCAGAAAACCGTCTTGCGGTCGCAACCCGCGACATCAATCCTTTCGAGGCTGCTGGGTTGAAGGTGA
TCAACCCTTGGATCCTACAGCAATTAAGTTGA
ATGATCTTGCTTGATACCAACGTGATATCGGAGCCTTGGAAACCGGCCCCTGACGAGACAGTGGTCGCCTGGCTGGACGC
GCAAGCAGTTGAGACGCTGTTTATCTCAGCGATAACAATTGCCGAACTGCGTTTTGGGATCGCCGCCATGCCCGCTGGGA
AACGGCAAACTATTCTCCGTGATCGCCTGGAGGTCGAAGTGCTTCCGCATTTTGCGGGGCGTATCCTGCCTTTTGGCGTT
GCCACGTCGCAGTTTTATTCGGAACTGATGGTGCGCGCTCGGTTGTCCGGTAAGGCGATCGGCGAGGCCGATGGATATAT
TGCAGCCACGGCAGCAGAAAACCGTCTTGCGGTCGCAACCCGCGACATCAATCCTTTCGAGGCTGCTGGGTTGAAGGTGA
TCAACCCTTGGATCCTACAGCAATTAAGTTGA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8961.20 Da Isoelectric Point: 4.5358
>AT224020 WP_109678913.1 NZ_CP086615:3373071-3373307 [Spiribacter sp. E85]
MATTAKIFTSGRSQAVRLPKSLRFEGTEVIAKRFGNGVLLLPVDAPWEVMQEALEEFEPDFQMGREQPPLQDRDNWPW
MATTAKIFTSGRSQAVRLPKSLRFEGTEVIAKRFGNGVLLLPVDAPWEVMQEALEEFEPDFQMGREQPPLQDRDNWPW
Download Length: 237 bp
>AT224020 NZ_CP119567:c625910-625656 [Pararhizobium sp. T808]
ATGCCGGCTGTTATCATTCGCAATCTGTCCGAGGAAACGCATCGCGCTTTAAAGGTGCGAGCAGCTCACCATGGCCGAAG
CACCGAGGCGGAAATCAGGGACATTATTGAAGCGGCTGTTCGTCCCGCTGAGCGTGTCAAACTCGGGTCTTTACTGGCGG
CCATCGGCCGTGACGCGGAGCTTTCTGACACCGATGTTGAAGTGCTACAGCAAAACCGCGGTAAGGCACCCGCCGAGCCT
ATGACATTCGAATGA
ATGCCGGCTGTTATCATTCGCAATCTGTCCGAGGAAACGCATCGCGCTTTAAAGGTGCGAGCAGCTCACCATGGCCGAAG
CACCGAGGCGGAAATCAGGGACATTATTGAAGCGGCTGTTCGTCCCGCTGAGCGTGTCAAACTCGGGTCTTTACTGGCGG
CCATCGGCCGTGACGCGGAGCTTTCTGACACCGATGTTGAAGTGCTACAGCAAAACCGCGGTAAGGCACCCGCCGAGCCT
ATGACATTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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