Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2311176..2311723 Replicon chromosome
Accession NZ_CP086615
Organism Spiribacter sp. E85

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LMH63_RS10530 Protein ID WP_109675406.1
Coordinates 2311421..2311723 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LMH63_RS10525 Protein ID WP_109675743.1
Coordinates 2311176..2311433 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMH63_RS10490 (LMH63_10490) 2307010..2307723 + 714 WP_199225558.1 helix-turn-helix domain-containing protein -
LMH63_RS10495 (LMH63_10495) 2307844..2308557 + 714 WP_229332558.1 glutathione S-transferase family protein -
LMH63_RS10500 (LMH63_10500) 2308732..2309205 + 474 WP_109675398.1 GNAT family N-acetyltransferase -
LMH63_RS10505 (LMH63_10505) 2309224..2309328 + 105 Protein_2081 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
LMH63_RS10510 (LMH63_10510) 2309367..2309945 + 579 WP_199225559.1 DUF6151 family protein -
LMH63_RS10515 (LMH63_10515) 2310030..2310692 + 663 WP_109675402.1 phosphoribosylanthranilate isomerase -
LMH63_RS10520 (LMH63_10520) 2310708..2311103 - 396 WP_109675404.1 hypothetical protein -
LMH63_RS10525 (LMH63_10525) 2311176..2311433 + 258 WP_109675743.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LMH63_RS10530 (LMH63_10530) 2311421..2311723 + 303 WP_109675406.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMH63_RS10535 (LMH63_10535) 2312006..2315899 + 3894 WP_109675410.1 DUF3683 domain-containing protein -
LMH63_RS10540 (LMH63_10540) 2315990..2316229 + 240 WP_109675412.1 DNA-binding protein -
LMH63_RS10545 (LMH63_10545) 2316415..2316624 + 210 WP_199225560.1 type II toxin-antitoxin system HicB family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11606.40 Da        Isoelectric Point: 6.7205

>T224019 WP_109675406.1 NZ_CP086615:2311421-2311723 [Spiribacter sp. E85]
VAEVIWTEPAVQDLDSIAEYIALHNPPAARRLIENVFEKTGRLARFPHSGRVPPELPDSVFREMVVPPCRVFYRTEQGRV
LILHVMREERRLRAYLLEGD

Download         Length: 303 bp

>T224019 NZ_CP119567:346268-346783 [Pararhizobium sp. T808]
ATGCCTGACACGATCCGGCAGACGCTGACGCTGTGGCGCGCCTTCGTGCCGCGATGGGCCTTCGCGCCGCTTTCAGGCGA
AGGGGCGGCCCGTTTTGGCGGACGCTGGAACCCGGTGGGTGCAGCCACCATCTACGCGGCCCGCGAACTCTCGACCGCCT
GGGCCGAATACAATCAGGGTTTTGTCCAGCATCCGGCGCTGATCGCGCAGCTCGACCTCAAGCAGGCGGCACTCGCCGAT
CTGACTGATCCGCAGGTATTGTCCGATCTTGCCGTACCGGATGATATTCATCATTGCGAATGGCGGATGCTTCTCGACGC
GGGCAAGGTGCCGCCGACCCACCATCTGCGGCAGCGGCTGATCGCCGACGGGTTTGACGGCGTCGTCTATCCATCCTTCA
TGTCGCCGGGCGGGACCTGCGTGGCGCTCTGGCGCTGGAACGGAAAGGGTGCGCCGCGTCTCGACGTGGTCGATCCGGAT
GGCCGCCTGCCGAAGACCCGGGCATCGTGGGTCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9863.38 Da        Isoelectric Point: 8.5041

>AT224019 WP_109675743.1 NZ_CP086615:2311176-2311433 [Spiribacter sp. E85]
MKVELVTTLKRQATKILAELHESKEPVLITEHGKPSAYLVDVQDYELMQRRLDLLEGLSRGERAVLEGRTYSQNEARERL
GKWLK

Download         Length: 258 bp

>AT224019 NZ_CP119567:345904-346275 [Pararhizobium sp. T808]
ATGACAGCTTTGAGCTTTGATATGACGGCAAGCCGGTTTGGCGACGGTCAATCGCCGTTTCTGTCGGCGGAGCGGGTCTC
CAAGCAGCTCGGTGTCACCTTGTCCGAGCTTGCCAAGCTGATCGGCGTTGCCCGCAATACGTTGAACGCGAAATCTGGCG
CGCGCAAGGTGGATCATGCGCTGAGCCATGTGGTGCGCATCCTTTCCATGGCCAGCGAAATGGCTGGGGATGACAACCGC
GCGACCATCTGGTTCAAGCATCAGCCGATCCCCGGCTGGGCGGGCAAGACCGCCTATGATCTGGTGAGCGAAGGCAAATC
GGACAAGGTGCTGGCCTATCTCGAGGCGGTGCGATCCGGCGTTTATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References