Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 14650..15170 Replicon plasmid unnamed4
Accession NZ_CP086614
Organism Shinella zoogloeoides strain ATCC 19623

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K8M09_RS23525 Protein ID WP_229342565.1
Coordinates 14650..14844 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K8M09_RS23530 Protein ID WP_206366716.1
Coordinates 14841..15170 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M09_RS23515 (K8M09_23510) 10366..12729 - 2364 WP_160788012.1 M48 family metalloprotease -
K8M09_RS23520 (K8M09_23515) 12756..14489 - 1734 WP_160788013.1 type IV secretory system conjugative DNA transfer family protein -
K8M09_RS23525 (K8M09_23520) 14650..14844 + 195 WP_229342565.1 type II toxin-antitoxin system HicA family toxin Toxin
K8M09_RS23530 (K8M09_23525) 14841..15170 + 330 WP_206366716.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K8M09_RS23535 (K8M09_23530) 15295..15558 + 264 WP_160788014.1 type II toxin-antitoxin system ParD family antitoxin -
K8M09_RS23540 (K8M09_23535) 15555..15854 + 300 WP_160788015.1 type II toxin-antitoxin system RelE/ParE family toxin -
K8M09_RS23545 (K8M09_23540) 16199..17317 + 1119 WP_160788016.1 MobA/MobL family protein -
K8M09_RS23550 (K8M09_23545) 17514..17906 + 393 WP_160788017.1 hypothetical protein -
K8M09_RS23555 (K8M09_23550) 17907..18197 - 291 WP_160788018.1 hypothetical protein -
K8M09_RS23560 (K8M09_23555) 18194..19093 - 900 WP_160788019.1 phage integrase N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34705 34705


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-54)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7121.22 Da        Isoelectric Point: 9.4120

>T224018 WP_229342565.1 NZ_CP086614:14650-14844 [Shinella zoogloeoides]
IPWRDIEAMLAACGAEITEGQGSRVRIALNGVRAVFHRPHPQKETDKGAVKSVRRFLLEAEIQP

Download         Length: 195 bp

>T224018 NZ_CP119566:c3665105-3664824 [Pararhizobium sp. T808]
GTGATCCGTTCTTTCAAGGGCAAGATATCTGCGGCCCTGGCCGATGGCAGTATGAAGAAGGGGTTTCCCACCGATCTCGT
CCGGCGTGCCCAGCAATTGCTGGTGTTGTTGAATGCAGCCTGCGACGTGAAGGACCTGCGCTCGCCTCCCGGCAATCGGC
TGGAGAAATTGTCGGGAGACCGTGAAGGTCAGTATTCGATCCGTATCAATCAGCAATGGCGCATCTGTTTCGTGTGGTCG
AATGGCGGCGCCGATGACGTGGAAATCGTTGATTACCATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12111.67 Da        Isoelectric Point: 4.6207

>AT224018 WP_206366716.1 NZ_CP086614:14841-15170 [Shinella zoogloeoides]
MTMMHYKGYEAVVEFDEEAEIFHGEVINLRDVITFQGASAAELKQAFAESVEDYLAFCAERGEEPEKPFSGQFVVRTEPG
LHKALTVAARRAGVSLNKWVTSTLERAVG

Download         Length: 330 bp

>AT224018 NZ_CP119566:c3664807-3664508 [Pararhizobium sp. T808]
ATGAACGATATCGGCCTGCCGGCCATCCATCCGGGCGAGATTCTCAAGGATCTCTATCTCGAGCCGCTGGATATAAGCGC
GGGAACGCTCGCCAAGAAGCTGAATGTCCCAAGAACCCGCATCGAACGGATCGTTACGGGCAAGACTGGCGTGACCTCCG
ATACCGCGCTGCGTCTTGCCAGGTTTTTCGACACCACGCCCGAACTCTGGATGAATTTGCAGGTCAGCTACGACCTGACG
ATCGAGGCTGAACGCAAACGGGCCGAGATTGAGCGCATTCCCGTGCGCGATGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References