Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1022048..1022679 Replicon chromosome
Accession NZ_CP086610
Organism Shinella zoogloeoides strain ATCC 19623

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K8M09_RS05065 Protein ID WP_160784973.1
Coordinates 1022281..1022679 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K8M09_RS05060 Protein ID WP_160784974.1
Coordinates 1022048..1022281 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M09_RS05045 (K8M09_05040) 1017508..1020354 + 2847 WP_160784977.1 DUF2339 domain-containing protein -
K8M09_RS05050 (K8M09_05045) 1020391..1021044 + 654 WP_160784976.1 HD domain-containing protein -
K8M09_RS05055 (K8M09_05050) 1021123..1021968 + 846 WP_160784975.1 MOSC domain-containing protein -
K8M09_RS05060 (K8M09_05055) 1022048..1022281 + 234 WP_160784974.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K8M09_RS05065 (K8M09_05060) 1022281..1022679 + 399 WP_160784973.1 tRNA(fMet)-specific endonuclease VapC Toxin
K8M09_RS05070 (K8M09_05065) 1022710..1023702 - 993 WP_160784972.1 magnesium transporter CorA family protein -
K8M09_RS05075 (K8M09_05070) 1024003..1025238 + 1236 WP_160784971.1 MFS transporter -
K8M09_RS05080 (K8M09_05075) 1025404..1026483 + 1080 WP_160784970.1 quinolinate synthase NadA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14727.06 Da        Isoelectric Point: 7.3515

>T224014 WP_160784973.1 NZ_CP086610:1022281-1022679 [Shinella zoogloeoides]
MLAYMLDTNICIYVMKTYPPAVREKFNALAEQLCISSITLAELHYGAEKSARRAENLMAIEHFVARLEVLPFAARAAAHY
GQVRAELERAGTPCGPHDMQIGGHARSEGLIVVTNNLREFARMPGLRAENWL

Download         Length: 399 bp

>T224014 NZ_CP119566:3479456-3479644 [Pararhizobium sp. T808]
ATACTTAGCTCCGATGTCATTTCCAATCTGAGGAAGGACGGCTGGTACGAGGTGGCTAGAAAGGGCAGTCATGTCCAATT
CAAGCACCCCGGCAAGCCTGGTCGAGTGACGGTTCCCCACCCTAGGCGTGACATTCCCATCGGAACGCTGAAAAGCATCG
AAAAGCAGGCCGACTTAAAACTGAGGTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8740.84 Da        Isoelectric Point: 5.0493

>AT224014 WP_160784974.1 NZ_CP086610:1022048-1022281 [Shinella zoogloeoides]
MANSTVFTSNRSQAVRLPKAVAFPEDVHVVDVLKIGRSRVIVPQGQRWDDLFLNGPRVSDDFMPEREQPAAEERESF

Download         Length: 234 bp

>AT224014 NZ_CP119566:3479649-3480053 [Pararhizobium sp. T808]
ATGCGCAATTATATCGGACTGATCCACAAGGACCCCGGCAGCGACTATGGCGTGTCCTTTCCCGATTTTCCCGGCGTGAT
CTCGGCAGGCACCGATCTCGACGACGCCCGGCAGATGGCGAGCGAAGCTTTGGCATTTCATTTGGAAGGTCTGGTTGAGG
ATGGATCCAACATTCCAGAGCCCTCCAGCCTCGAAAACATCATGGCCGATGCGGACAACAGAAAAGGCGTTGCCATTCTT
GTCGGAGTGAGGATGGAGACGAAGAAGGCTGTGCGTGTCAATGTCACGCTTCCGGAAGATGTTCTTCGCCAGATTGACCG
GTTTGCCGAATCCAAGGGATTGACGCGGTCCGGGTTCATCGCGCTTGCCGCCCTGCACGAGATCGACCGGGACGATGCGG
CCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References