Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 763769..764310 Replicon chromosome
Accession NZ_CP086610
Organism Shinella zoogloeoides strain ATCC 19623

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K8M09_RS03745 Protein ID WP_160785472.1
Coordinates 763987..764310 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K8M09_RS03740 Protein ID WP_160785471.1
Coordinates 763769..763990 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8M09_RS03720 (K8M09_03715) 759854..760309 - 456 WP_229342139.1 RT0821/Lpp0805 family surface protein -
K8M09_RS03725 (K8M09_03720) 760354..760974 + 621 WP_160785469.1 pyridoxamine 5'-phosphate oxidase -
K8M09_RS03730 (K8M09_03725) 761009..762085 - 1077 WP_229342140.1 polysaccharide deacetylase family protein -
K8M09_RS03735 (K8M09_03730) 762167..763582 - 1416 WP_160785470.1 metalloprotease TldD -
K8M09_RS03740 (K8M09_03735) 763769..763990 + 222 WP_160785471.1 antitoxin MazE family protein Antitoxin
K8M09_RS03745 (K8M09_03740) 763987..764310 + 324 WP_160785472.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K8M09_RS03750 (K8M09_03745) 764319..764849 - 531 WP_229342142.1 invasion associated locus B family protein -
K8M09_RS03755 (K8M09_03750) 765273..766157 + 885 WP_160785473.1 cytochrome c oxidase subunit II -
K8M09_RS03760 (K8M09_03755) 766176..767843 + 1668 WP_160785474.1 cytochrome c oxidase subunit I -
K8M09_RS03765 (K8M09_03760) 768031..768975 + 945 WP_160785475.1 heme o synthase -
K8M09_RS03770 (K8M09_03765) 768975..769115 + 141 WP_170299444.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(6-68)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11455.38 Da        Isoelectric Point: 8.6150

>T224013 WP_160785472.1 NZ_CP086610:763987-764310 [Shinella zoogloeoides]
VKRGDLVTVAIPGDFGKPRPALIIQSDLFSEAATVTVLLVSGTYQDAPLLRIPVEPDALNGLKKSSQVMVDKAMTIRREK
IGETIGRLDAETMASVSRSLALFLGFA

Download         Length: 324 bp

>T224013 NZ_CP119566:c3320396-3319974 [Pararhizobium sp. T808]
GTGAGCGGCCTGGTTTACATGCTCGATACGAACATTCTCTCGGATACGATCCGCAATCCGTTTGGCGTTGCCAGCCAGTA
TATGGAGCGGGTCAGTGAGGATGCGCTTTGCGTGAGCGCCATCGTTGCCTCCGAGATGCGTTACGGGATCAGGAAAAAGG
GATCGCCCCGGCTATCCTATCTCGTCGAGAATACTTTATCCCGCATCGCCATCCTTCCTTATGACGACGCGGCCTCGCAG
AGCTACAGCGTCATACGCACTGCTCTGGAACGTCAGGGCAAATCGATCGGCTTGGCCGACCTCTTGATCGCCGCCCATGC
ACTGTCGCTTGGTCTGACCATCGTCACAAACAACACCCGTGAATTTTCGCGGGTCGAGGGTTTGACGATTGAAAACTGGC
TGGCGGCGGAGGAGCATCCATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8122.21 Da        Isoelectric Point: 5.0633

>AT224013 WP_160785471.1 NZ_CP086610:763769-763990 [Shinella zoogloeoides]
MPKAVNERVQKRRDALRANGLRPVQMWLPDTRRGGFAEECARQARIIAAAEVDDRDLDGLLDAAFLDLVGSDT

Download         Length: 222 bp

>AT224013 NZ_CP119566:c3320647-3320393 [Pararhizobium sp. T808]
ATGACTGTGATCCATGTGGATGAGGGACGCGAGGTCAAACTCTTTCGCAACGGCCGTAACCAGGCCGTCCGCATTCCCGT
GGAATTCGAACTGCCGGGAAACGAGGCGATCATGCGCAAGGAAGGCGACTGCTTGATCATCGAGCCGAAAAAGAAGAGCG
GATTGCTGGAATGGCTTCGGGCGCAGGAGCCGCTGGACGAGGAGTTCCCTGATCTGGATGAAAAGAGCCCTCCGCCGAAG
GATTTCGATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References