Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 7053..7546 | Replicon | plasmid pEF45-4 |
| Accession | NZ_CP086608 | ||
| Organism | Escherichia fergusonii strain EF20JDJ4045 | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | U9Y9W8 |
| Locus tag | LNN29_RS24635 | Protein ID | WP_001230709.1 |
| Coordinates | 7053..7307 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | U9Y4R8 |
| Locus tag | LNN29_RS24640 | Protein ID | WP_000151456.1 |
| Coordinates | 7304..7546 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN29_RS24590 (LNN29_24540) | 2570..2722 | + | 153 | Protein_2 | DUF5431 family protein | - |
| LNN29_RS24595 (LNN29_24545) | 2667..2789 | + | 123 | WP_223685802.1 | Hok/Gef family protein | - |
| LNN29_RS24600 (LNN29_24550) | 2939..3535 | + | 597 | WP_000125165.1 | ProQ/FINO family protein | - |
| LNN29_RS24605 (LNN29_24555) | 3553..3837 | - | 285 | WP_001162371.1 | hypothetical protein | - |
| LNN29_RS24610 (LNN29_24560) | 3911..4576 | - | 666 | WP_000532149.1 | division plane positioning ATPase MipZ | - |
| LNN29_RS24615 (LNN29_24565) | 4800..5033 | + | 234 | WP_057520283.1 | hypothetical protein | - |
| LNN29_RS24620 (LNN29_24570) | 5165..5494 | + | 330 | WP_001542022.1 | hypothetical protein | - |
| LNN29_RS24625 (LNN29_24575) | 5895..6410 | + | 516 | WP_001025393.1 | J domain-containing protein | - |
| LNN29_RS24630 (LNN29_24580) | 6514..7056 | + | 543 | WP_001083904.1 | hypothetical protein | - |
| LNN29_RS24635 (LNN29_24585) | 7053..7307 | + | 255 | WP_001230709.1 | hypothetical protein | Toxin |
| LNN29_RS24640 (LNN29_24590) | 7304..7546 | + | 243 | WP_000151456.1 | hypothetical protein | Antitoxin |
| LNN29_RS24645 (LNN29_24595) | 7767..7985 | + | 219 | WP_154101533.1 | hypothetical protein | - |
| LNN29_RS24650 (LNN29_24600) | 8117..8410 | + | 294 | WP_000673428.1 | hypothetical protein | - |
| LNN29_RS24655 (LNN29_24605) | 8899..9147 | + | 249 | WP_000513532.1 | type II toxin-antitoxin system HicA family toxin | - |
| LNN29_RS24660 (LNN29_24610) | 9144..9491 | + | 348 | WP_000681609.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LNN29_RS24665 (LNN29_24615) | 9579..10022 | - | 444 | WP_023223351.1 | hypothetical protein | - |
| LNN29_RS24670 (LNN29_24620) | 10263..10562 | + | 300 | WP_034169410.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LNN29_RS24675 (LNN29_24625) | 10822..11148 | - | 327 | WP_000206697.1 | hypothetical protein | - |
| LNN29_RS24680 (LNN29_24630) | 11150..11473 | - | 324 | WP_223666488.1 | hypothetical protein | - |
| LNN29_RS24685 (LNN29_24635) | 11450..11590 | - | 141 | Protein_21 | hypothetical protein | - |
| LNN29_RS24690 (LNN29_24640) | 11610..12317 | - | 708 | WP_000108794.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | mcr-1.1 | - | 1..61140 | 61140 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9942.47 Da Isoelectric Point: 10.1206
>T224010 WP_001230709.1 NZ_CP086608:7053-7307 [Escherichia fergusonii]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA
Download Length: 255 bp
>T224010 NZ_CP119566:1809916-1810173 [Pararhizobium sp. T808]
ATTGATCTTTCCGACGCTGCCGATAAAACATTGCGGAAAATCAGCAAATCCGACGCAAAACGGATTGCGGGCTTTCTCTA
CCAGCGGGTGACGGCACTCGACAATCCCCGGCAACTTGGCCAGGCTTTGCAAGGTTCGAAACTGGGCGATCTGTGGCGCT
ATAGAGTTGGAGATTTTCGAGTTCTTTGCAAAATCCAGGACAGCCGTCTGGTTGTTCTGGTTATCGAAATCGGGCATCGC
CGCGATATCTACAGATAA
ATTGATCTTTCCGACGCTGCCGATAAAACATTGCGGAAAATCAGCAAATCCGACGCAAAACGGATTGCGGGCTTTCTCTA
CCAGCGGGTGACGGCACTCGACAATCCCCGGCAACTTGGCCAGGCTTTGCAAGGTTCGAAACTGGGCGATCTGTGGCGCT
ATAGAGTTGGAGATTTTCGAGTTCTTTGCAAAATCCAGGACAGCCGTCTGGTTGTTCTGGTTATCGAAATCGGGCATCGC
CGCGATATCTACAGATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9136.45 Da Isoelectric Point: 7.2775
>AT224010 WP_000151456.1 NZ_CP086608:7304-7546 [Escherichia fergusonii]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP
Download Length: 243 bp
>AT224010 NZ_CP119566:1809687-1809920 [Pararhizobium sp. T808]
ATGGCCAAGCAAACAGCAATCCGTCTTTCCGACGAGACCTATGAAAGATTGCAGGCTCTCGCCGCGCGCACCGGACGGAC
GGCGACATTCTATATTCGCCAGGCGATCGAAGAGCATCTGGAAGATCTTGAAGACATCTATCTTGCCGAGAGTGTCTTGG
AGAAAATCCAGAGAGGCGAAATGGGCACGCGGCCGCTCAAAGAGGCGATGGAAGAACTTGGCCTGGACGATTGA
ATGGCCAAGCAAACAGCAATCCGTCTTTCCGACGAGACCTATGAAAGATTGCAGGCTCTCGCCGCGCGCACCGGACGGAC
GGCGACATTCTATATTCGCCAGGCGATCGAAGAGCATCTGGAAGATCTTGAAGACATCTATCTTGCCGAGAGTGTCTTGG
AGAAAATCCAGAGAGGCGAAATGGGCACGCGGCCGCTCAAAGAGGCGATGGAAGAACTTGGCCTGGACGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9H8F0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G9GNF5 |