Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1914564..1915183 Replicon chromosome
Accession NZ_CP086604
Organism Escherichia fergusonii strain EF20JDJ4045

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LNN29_RS09380 Protein ID WP_001280991.1
Coordinates 1914965..1915183 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag LNN29_RS09375 Protein ID WP_000344803.1
Coordinates 1914564..1914938 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN29_RS09365 (1909696) 1909696..1910889 + 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LNN29_RS09370 (1910912) 1910912..1914061 + 3150 WP_001132493.1 efflux RND transporter permease AcrB -
LNN29_RS09375 (1914564) 1914564..1914938 + 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
LNN29_RS09380 (1914965) 1914965..1915183 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LNN29_RS09385 (1915680) 1915680..1916150 + 471 WP_002431406.1 YlaC family protein -
LNN29_RS09390 (1916289) 1916289..1917839 + 1551 WP_001260376.1 EAL domain-containing protein -
LNN29_RS09395 (1917881) 1917881..1918234 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LNN29_RS09405 (1918613) 1918613..1918924 + 312 WP_000409911.1 MGMT family protein -
LNN29_RS09410 (1918955) 1918955..1919527 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T223987 WP_001280991.1 NZ_CP086604:1914965-1915183 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T223987 NZ_CP119531:c4579963-4579553 [Raoultella electrica]
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGTTCACAGTGGTTCTCGCTGCTGCTACATGGCGTTGTGGCGGC
TATTGTGCTGCTGATGCCGTGGCCGCTGAGCTACACACCGCTTTGGCTACTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCA
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGCCTGCAGGATATGCAAACACGCCGCCG
CCAGCATCTGTGGGTCGCTGCAGACAGTATGGATGCCAGAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT223987 WP_000344803.1 NZ_CP086604:1914564-1914938 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT223987 NZ_CP119531:c4580210-4579944 [Raoultella electrica]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCCGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTCATCCGCCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References