Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF-RHH |
| Location | 309129..309691 | Replicon | chromosome |
| Accession | NZ_CP086599 | ||
| Organism | Nocardia farcinica strain SZ 1509 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | - |
| Locus tag | LMJ57_RS01415 | Protein ID | WP_098086269.1 |
| Coordinates | 309129..309440 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | - |
| Locus tag | LMJ57_RS01420 | Protein ID | WP_216641984.1 |
| Coordinates | 309437..309691 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMJ57_RS01395 (LMJ57_01395) | 305687..305908 | + | 222 | WP_098086264.1 | hypothetical protein | - |
| LMJ57_RS01400 (LMJ57_01400) | 305997..306596 | - | 600 | WP_127516287.1 | HEPN domain-containing protein | - |
| LMJ57_RS01405 (LMJ57_01405) | 306602..307654 | - | 1053 | WP_098087100.1 | ParA family protein | - |
| LMJ57_RS01410 (LMJ57_01410) | 307852..308640 | - | 789 | WP_098086267.1 | toll/interleukin-1 receptor domain-containing protein | - |
| LMJ57_RS01415 (LMJ57_01415) | 309129..309440 | - | 312 | WP_098086269.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LMJ57_RS01420 (LMJ57_01420) | 309437..309691 | - | 255 | WP_216641984.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
| LMJ57_RS31295 | 310336..311154 | - | 819 | WP_076573695.1 | hypothetical protein | - |
| LMJ57_RS01435 (LMJ57_01435) | 311317..312276 | - | 960 | WP_060593777.1 | metallophosphoesterase | - |
| LMJ57_RS01440 (LMJ57_01440) | 312455..312919 | + | 465 | WP_098086277.1 | GatB/YqeY domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 11259.82 Da Isoelectric Point: 5.0338
>T223977 WP_098086269.1 NZ_CP086599:c309440-309129 [Nocardia farcinica]
VNAPVRGQVYRADLGYGPKPWLIVSNNQRNRVTLDVLAVRITTTRRELPTWVELGSNEPLTGFVNTDNIETLAKDELGDY
LGSLSASAILEVNRALTIALGIP
VNAPVRGQVYRADLGYGPKPWLIVSNNQRNRVTLDVLAVRITTTRRELPTWVELGSNEPLTGFVNTDNIETLAKDELGDY
LGSLSASAILEVNRALTIALGIP
Download Length: 312 bp
>T223977 NZ_CP119528:3072859-3073002 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9607.68 Da Isoelectric Point: 5.7134
>AT223977 WP_216641984.1 NZ_CP086599:c309691-309437 [Nocardia farcinica]
MTHAMTVRLDDETFRRLQELEQAGAPSRSAAVVAAIHEAWNRLQDEQLARAYEAAVAQSPTYPYEDEDERAVLRARRNKR
QIPA
MTHAMTVRLDDETFRRLQELEQAGAPSRSAAVVAAIHEAWNRLQDEQLARAYEAAVAQSPTYPYEDEDERAVLRARRNKR
QIPA
Download Length: 255 bp
>AT223977 NZ_CP119528:c3072748-3072606 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|