Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-RHH
Location 309129..309691 Replicon chromosome
Accession NZ_CP086599
Organism Nocardia farcinica strain SZ 1509

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LMJ57_RS01415 Protein ID WP_098086269.1
Coordinates 309129..309440 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LMJ57_RS01420 Protein ID WP_216641984.1
Coordinates 309437..309691 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMJ57_RS01395 (LMJ57_01395) 305687..305908 + 222 WP_098086264.1 hypothetical protein -
LMJ57_RS01400 (LMJ57_01400) 305997..306596 - 600 WP_127516287.1 HEPN domain-containing protein -
LMJ57_RS01405 (LMJ57_01405) 306602..307654 - 1053 WP_098087100.1 ParA family protein -
LMJ57_RS01410 (LMJ57_01410) 307852..308640 - 789 WP_098086267.1 toll/interleukin-1 receptor domain-containing protein -
LMJ57_RS01415 (LMJ57_01415) 309129..309440 - 312 WP_098086269.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LMJ57_RS01420 (LMJ57_01420) 309437..309691 - 255 WP_216641984.1 ribbon-helix-helix protein, CopG family Antitoxin
LMJ57_RS31295 310336..311154 - 819 WP_076573695.1 hypothetical protein -
LMJ57_RS01435 (LMJ57_01435) 311317..312276 - 960 WP_060593777.1 metallophosphoesterase -
LMJ57_RS01440 (LMJ57_01440) 312455..312919 + 465 WP_098086277.1 GatB/YqeY domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11259.82 Da        Isoelectric Point: 5.0338

>T223977 WP_098086269.1 NZ_CP086599:c309440-309129 [Nocardia farcinica]
VNAPVRGQVYRADLGYGPKPWLIVSNNQRNRVTLDVLAVRITTTRRELPTWVELGSNEPLTGFVNTDNIETLAKDELGDY
LGSLSASAILEVNRALTIALGIP

Download         Length: 312 bp

>T223977 NZ_CP119528:3072859-3073002 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9607.68 Da        Isoelectric Point: 5.7134

>AT223977 WP_216641984.1 NZ_CP086599:c309691-309437 [Nocardia farcinica]
MTHAMTVRLDDETFRRLQELEQAGAPSRSAAVVAAIHEAWNRLQDEQLARAYEAAVAQSPTYPYEDEDERAVLRARRNKR
QIPA

Download         Length: 255 bp

>AT223977 NZ_CP119528:c3072748-3072606 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References