Detailed information of TA system TA223976

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2662079..2662596
• Replicon: chromosome
• Accession: NZ_CP086594
• Organism: Sphingomonas radiodurans strain S9-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LLW23_RS12395
• Protein ID: WP_228945823.1
• Coordinates: 2662079..2662345 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LLW23_RS12400
• Protein ID: WP_228945824.1
• Coordinates: 2662342..2662596 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLW23_RS12375 (LLW23_12410)	2657276..2659135	+	1860	WP_228945819.1	phosphomethylpyrimidine synthase ThiC	-
LLW23_RS12380 (LLW23_12415)	2659312..2660064	+	753	WP_228945820.1	DUF4019 domain-containing protein	-
LLW23_RS12390 (LLW23_12425)	2661836..2662075	+	240	WP_228945822.1	hypothetical protein	-
LLW23_RS12395 (LLW23_12430)	2662079..2662345	-	267	WP_228945823.1	Txe/YoeB family addiction module toxin	Toxin
LLW23_RS12400 (LLW23_12435)	2662342..2662596	-	255	WP_228945824.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LLW23_RS12405 (LLW23_12440)	2662811..2663560	+	750	WP_228945825.1	phosphatase PAP2 family protein	-
LLW23_RS12410 (LLW23_12445)	2663632..2664093	+	462	WP_228945826.1	DUF6456 domain-containing protein	-
LLW23_RS12415 (LLW23_12450)	2664279..2665208	+	930	WP_228948572.1	diaminopimelate epimerase	-
LLW23_RS12420 (LLW23_12455)	2665218..2666798	-	1581	WP_228948573.1	acyl-CoA dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10250.49 Da
• Isoelectric Point: 9.1141

>T223976 WP_228945823.1 NZ_CP086594:c2662345-2662079 [Sphingomonas radiodurans]
VILTFSSRAWSEYLEWQGDDRRGLERVNALIKECQRDPFRGTGKPEPLGGNLSGWWSRRINREHRLVYRVSGAGDAQALE
IAQCRYHY

Nucleotide

• Length: 267 bp

>T223976 NZ_CP119528:3068211-3068315 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9054.36 Da
• Isoelectric Point: 4.5510

>AT223976 WP_228945824.1 NZ_CP086594:c2662596-2662342 [Sphingomonas radiodurans]
MQSLSISEARANMKALVDRVVADKAPVSITRQKGEGVVMISQSEWSSIEETLYLLQSPANAKRLLESIGELDAGAGVERA
LIEP

Nucleotide

• Length: 255 bp

>AT223976 NZ_CP119528:c3068503-3068248 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTATTTAAA
AATAACCGTGCTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA