223975

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 44344..44840 Replicon plasmid pFac74-1
Accession NZ_CP086593
Organism Enterococcus faecalis strain Fac74

Toxin (Protein)


Gene name relE Uniprot ID R3GZA4
Locus tag LNB41_RS15070 Protein ID WP_002358470.1
Coordinates 44344..44613 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R3JPM7
Locus tag LNB41_RS15075 Protein ID WP_002413218.1
Coordinates 44613..44840 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNB41_RS15060 (LNB41_15055) 39723..42689 - 2967 WP_229023975.1 N-6 DNA methylase -
LNB41_RS15065 (LNB41_15060) 42697..44277 - 1581 WP_002404189.1 DUF3991 domain-containing protein -
LNB41_RS15070 (LNB41_15065) 44344..44613 - 270 WP_002358470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LNB41_RS15075 (LNB41_15070) 44613..44840 - 228 WP_002413218.1 DUF6290 family protein Antitoxin
LNB41_RS15080 (LNB41_15075) 44900..46135 - 1236 WP_010785148.1 MobP2 family relaxase -
LNB41_RS15085 (LNB41_15080) 46138..46695 - 558 WP_002358242.1 hypothetical protein -
LNB41_RS15090 (LNB41_15085) 46688..46948 - 261 WP_010707423.1 ribbon-helix-helix protein, CopG family -
LNB41_RS15095 (LNB41_15090) 47370..48194 - 825 WP_010715712.1 hypothetical protein -
LNB41_RS15100 (LNB41_15095) 48209..48733 - 525 WP_002358238.1 hypothetical protein -
LNB41_RS15105 (LNB41_15100) 48751..49725 - 975 WP_229023976.1 glucosaminidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(A) / optrA / fexA asa1 1..69345 69345


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 10.5395

>T223975 WP_002358470.1 NZ_CP086593:c44613-44344 [Enterococcus faecalis]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTANPREHGKALSANRAGQWRYRIGNYRVIVEIEDERLVVTAIQV
GHRRNVYDK

Download         Length: 270 bp

>T223975 NZ_CP119528:3068211-3068315 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8785.90 Da        Isoelectric Point: 4.0179

>AT223975 WP_002413218.1 NZ_CP086593:c44840-44613 [Enterococcus faecalis]
MAMITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Download         Length: 228 bp

>AT223975 NZ_CP119528:c3068071-3067917 [Enterococcus faecalis]
TTTTTAGGTAAGTGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCGGTTTAAGA
CGGTGACCTTTTGGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3GZA4

Antitoxin

Source ID Structure
AlphaFold DB R3JPM7

References