Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 1629205..1630342 | Replicon | chromosome |
| Accession | NZ_CP086592 | ||
| Organism | Enterococcus faecalis strain Fac74 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | LNB41_RS08015 | Protein ID | WP_002401483.1 |
| Coordinates | 1629205..1630068 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | R2XCR7 |
| Locus tag | LNB41_RS08020 | Protein ID | WP_000301765.1 |
| Coordinates | 1630070..1630342 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNB41_RS07985 (1625100) | 1625100..1625867 | - | 768 | WP_002357481.1 | ribonuclease HII | - |
| LNB41_RS07990 (1625869) | 1625869..1626720 | - | 852 | WP_002357480.1 | ribosome biogenesis GTPase YlqF | - |
| LNB41_RS07995 (1626996) | 1626996..1627427 | - | 432 | Protein_1548 | 2-dehydropantoate 2-reductase | - |
| LNB41_RS08000 (1627483) | 1627483..1628163 | - | 681 | WP_010710189.1 | IS6-like element IS1216 family transposase | - |
| LNB41_RS08005 (1628239) | 1628239..1628427 | - | 189 | Protein_1550 | DnaJ domain-containing protein | - |
| LNB41_RS08010 (1628447) | 1628447..1628764 | - | 318 | WP_002333463.1 | hypothetical protein | - |
| LNB41_RS08015 (1629205) | 1629205..1630068 | - | 864 | WP_002401483.1 | zeta toxin family protein | Toxin |
| LNB41_RS08020 (1630070) | 1630070..1630342 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
| LNB41_RS08025 (1630359) | 1630359..1630574 | - | 216 | WP_002295735.1 | peptide-binding protein | - |
| LNB41_RS08030 (1630645) | 1630645..1631541 | - | 897 | WP_002387620.1 | ParA family protein | - |
| LNB41_RS08035 (1631644) | 1631644..1631904 | - | 261 | Protein_1556 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| LNB41_RS08040 (1632074) | 1632074..1632811 | - | 738 | WP_002292226.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| LNB41_RS08045 (1632936) | 1632936..1633019 | - | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| LNB41_RS08050 (1633088) | 1633088..1633210 | - | 123 | Protein_1559 | peptide-binding protein | - |
| LNB41_RS08055 (1633330) | 1633330..1634817 | - | 1488 | WP_229023913.1 | type IA DNA topoisomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | erm(B) / ant(6)-Ia / aac(6')-aph(2'') / cat / str | - | 1627483..1648615 | 21132 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32486.06 Da Isoelectric Point: 6.9965
>T223954 WP_002401483.1 NZ_CP086592:c1630068-1629205 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
Download Length: 864 bp
>T223954 NZ_CP119409:1711730-1712083 [Rhizobium gei]
GTGCGCCGCGTTGAGACCGTTGGAAGCGACAAGCTTTGCATCAGTGCGCTCGTGGCGTCTGAACTCCGCTATGGCGCGGT
GAAAAAACAATCGGAACGCCTGGCCTCGCTGATCGAAAACATCCTCGAACGCCTGGACATTGTGGCGTATGAAACCGCTG
CGACCGTGCATTACGCAGATATTCGGGACCAATTGACCGGCAGCGGCAACCTCATCGGCCCGATGGATCTTTTGATCGCC
GCGCATGCCCGTGCACTGGACCTGACTTTGGTGACCGACAACACCGCCGAATTTTCGCGCGTGGATGGGCTCAAGCTTGA
AAACTGGATCGCGGATCAGGAGACGGTGCCATGA
GTGCGCCGCGTTGAGACCGTTGGAAGCGACAAGCTTTGCATCAGTGCGCTCGTGGCGTCTGAACTCCGCTATGGCGCGGT
GAAAAAACAATCGGAACGCCTGGCCTCGCTGATCGAAAACATCCTCGAACGCCTGGACATTGTGGCGTATGAAACCGCTG
CGACCGTGCATTACGCAGATATTCGGGACCAATTGACCGGCAGCGGCAACCTCATCGGCCCGATGGATCTTTTGATCGCC
GCGCATGCCCGTGCACTGGACCTGACTTTGGTGACCGACAACACCGCCGAATTTTCGCGCGTGGATGGGCTCAAGCTTGA
AAACTGGATCGCGGATCAGGAGACGGTGCCATGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT223954 WP_000301765.1 NZ_CP086592:c1630342-1630070 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT223954 NZ_CP119409:1711407-1711661 [Rhizobium gei]
ATGACTGTGATCCAGGTTGATCAGGAGCGCGAGGTAAAACTCTTTCGCAACGGCCGCAATCAGGCCGTTCGCATCCCCGT
GGAGTTCGAGCTTCCGGGAAACGAGGCGATCATGCGCAAGGAGGGCGAGCGGCTGATCATCGAACCGAAAAGGAAAAGCG
GTTTGCTGGAATGGCTTCGCGCGCAGGAACCCTGGACCGAGGAGTTTCCGGACATTGATAAGGGAGTGCTGCCACTTGAG
GATGTCGATCTTTGA
ATGACTGTGATCCAGGTTGATCAGGAGCGCGAGGTAAAACTCTTTCGCAACGGCCGCAATCAGGCCGTTCGCATCCCCGT
GGAGTTCGAGCTTCCGGGAAACGAGGCGATCATGCGCAAGGAGGGCGAGCGGCTGATCATCGAACCGAAAAGGAAAAGCG
GTTTGCTGGAATGGCTTCGCGCGCAGGAACCCTGGACCGAGGAGTTTCCGGACATTGATAAGGGAGTGCTGCCACTTGAG
GATGTCGATCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|