Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2100613..2101127 Replicon chromosome
Accession NZ_CP086574
Organism Staphylococcus argenteus strain RIVM_M046968

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag LK342_RS10070 Protein ID WP_000233591.1
Coordinates 2100613..2100822 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LK342_RS10075 Protein ID WP_000138934.1
Coordinates 2100834..2101127 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK342_RS10050 (LK342_10050) 2095946..2097310 - 1365 WP_047528499.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LK342_RS10055 (LK342_10055) 2097325..2098395 - 1071 WP_047528497.1 D-alanine--D-alanine ligase -
LK342_RS10060 (LK342_10060) 2098714..2099916 + 1203 WP_047528495.1 FtsW/RodA/SpoVE family cell cycle protein -
LK342_RS10065 (LK342_10065) 2100347..2100484 - 138 WP_000828355.1 Lmo0850 family protein -
LK342_RS10070 (LK342_10070) 2100613..2100822 - 210 WP_000233591.1 heavy metal-associated domain-containing protein Toxin
LK342_RS10075 (LK342_10075) 2100834..2101127 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LK342_RS10080 (LK342_10080) 2101295..2102779 + 1485 WP_000571570.1 cardiolipin synthase -
LK342_RS10085 (LK342_10085) 2102808..2103455 + 648 WP_047528488.1 HD domain-containing protein -
LK342_RS10090 (LK342_10090) 2104109..2104978 - 870 WP_000725805.1 membrane protein insertase YidC -
LK342_RS10095 (LK342_10095) 2105064..2105705 - 642 WP_072368963.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T223943 WP_000233591.1 NZ_CP086574:c2100822-2100613 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T223943 NZ_CP119408:807331-807741 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT223943 WP_000138934.1 NZ_CP086574:c2101127-2100834 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT223943 NZ_CP119408:807084-807350 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References