Detailed information of TA system TA223941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1887401..1888188
• Replicon: chromosome
• Accession: NZ_CP086574
• Organism: Staphylococcus argenteus strain RIVM_M046968

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A7U7PZK3
• Locus tag: LK342_RS08820
• Protein ID: WP_000031103.1
• Coordinates: 1887401..1887556 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: LK342_RS08825
• Protein ID: WP_047526976.1
• Coordinates: 1887589..1888188 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK342_RS08800 (LK342_08800)	1882594..1883706	-	1113	WP_031787927.1	GAF domain-containing sensor histidine kinase	-
LK342_RS08805 (LK342_08805)	1883868..1884689	+	822	WP_250340815.1	RluA family pseudouridine synthase	-
LK342_RS08810 (LK342_08810)	1884980..1886365	-	1386	WP_047526974.1	class II fumarate hydratase	-
LK342_RS08815 (LK342_08815)	1886536..1886937	-	402	WP_047526975.1	hypothetical protein	-
LK342_RS08820 (LK342_08820)	1887401..1887556	-	156	WP_000031103.1	SAS053 family protein	Toxin
LK342_RS08825 (LK342_08825)	1887589..1888188	-	600	WP_047526976.1	glucosamine-6-phosphate isomerase	Antitoxin
LK342_RS08830 (LK342_08830)	1888347..1888817	-	471	WP_000181399.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LK342_RS08835 (LK342_08835)	1888819..1889949	-	1131	WP_047430471.1	tRNA epoxyqueuosine(34) reductase QueG	-
LK342_RS08840 (LK342_08840)	1890100..1890822	-	723	WP_047526977.1	amino acid ABC transporter ATP-binding protein	-
LK342_RS08845 (LK342_08845)	1890815..1892272	-	1458	WP_000649887.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6019.42 Da
• Isoelectric Point: 4.1469

>T223941 WP_000031103.1 NZ_CP086574:c1887556-1887401 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Nucleotide

• Length: 156 bp

>T223941 NZ_CP119405:20321-20608 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGGTTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22468.60 Da
• Isoelectric Point: 5.3935

>AT223941 WP_047526976.1 NZ_CP086574:c1888188-1887589 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDTIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT223941 NZ_CP119405:20073-20324 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Structures

Toxin

• AlphaFold DB: A0A7U7PZK3