Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 855790..856267 | Replicon | chromosome |
| Accession | NZ_CP086574 | ||
| Organism | Staphylococcus argenteus strain RIVM_M046968 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | A0A7U7JTG2 |
| Locus tag | LK342_RS03985 | Protein ID | WP_000172413.1 |
| Coordinates | 855790..855978 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | A0A7U7JTE3 |
| Locus tag | LK342_RS03990 | Protein ID | WP_000790107.1 |
| Coordinates | 856007..856267 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LK342_RS03955 (LK342_03955) | 851442..851912 | + | 471 | WP_047526196.1 | hypothetical protein | - |
| LK342_RS03960 (LK342_03960) | 852255..852923 | + | 669 | WP_047526197.1 | thermonuclease family protein | - |
| LK342_RS03965 (LK342_03965) | 853287..853487 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| LK342_RS03970 (LK342_03970) | 854099..854311 | - | 213 | WP_001007088.1 | hypothetical protein | - |
| LK342_RS03975 (LK342_03975) | 854372..854656 | - | 285 | WP_031788101.1 | hypothetical protein | - |
| LK342_RS03980 (LK342_03980) | 854745..855314 | - | 570 | WP_000668727.1 | lipoprotein N-acylation protein LnsA | - |
| LK342_RS03985 (LK342_03985) | 855790..855978 | - | 189 | WP_000172413.1 | hypothetical protein | Toxin |
| LK342_RS03990 (LK342_03990) | 856007..856267 | - | 261 | WP_000790107.1 | hypothetical protein | Antitoxin |
| LK342_RS03995 (LK342_03995) | 856607..856810 | + | 204 | WP_000145167.1 | sterile alpha motif-like domain-containing protein | - |
| LK342_RS04000 (LK342_04000) | 856807..857043 | - | 237 | WP_000368686.1 | hypothetical protein | - |
| LK342_RS04005 (LK342_04005) | 857268..857849 | + | 582 | WP_047526198.1 | histidine phosphatase family protein | - |
| LK342_RS04010 (LK342_04010) | 857916..858533 | - | 618 | WP_047526199.1 | LysE family transporter | - |
| LK342_RS04015 (LK342_04015) | 858697..859188 | - | 492 | WP_000695603.1 | GNAT family N-acetyltransferase | - |
| LK342_RS04020 (LK342_04020) | 859595..860017 | - | 423 | WP_001007646.1 | organic hydroperoxide resistance protein | - |
| LK342_RS04025 (LK342_04025) | 860166..860885 | + | 720 | WP_047526200.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7192.89 Da Isoelectric Point: 9.9971
>T223938 WP_000172413.1 NZ_CP086574:c855978-855790 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL
Download Length: 189 bp
>T223938 NZ_CP119404:c4014023-4013646 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 10089.30 Da Isoelectric Point: 4.1927
>AT223938 WP_000790107.1 NZ_CP086574:c856267-856007 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN
Download Length: 261 bp
>AT223938 NZ_CP119404:c4014444-4014070 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACTCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACTCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U7JTG2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U7JTE3 |