Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2732964..2733493 Replicon chromosome
Accession NZ_CP086572
Organism Staphylococcus argenteus strain RIVM_M036020

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U7JQG1
Locus tag LK336_RS13145 Protein ID WP_000621178.1
Coordinates 2733131..2733493 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LK336_RS13140 Protein ID WP_000948331.1
Coordinates 2732964..2733134 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK336_RS13115 (2728753) 2728753..2729232 + 480 WP_031787688.1 PH domain-containing protein -
LK336_RS13120 (2729225) 2729225..2730808 + 1584 WP_031787687.1 PH domain-containing protein -
LK336_RS13125 (2730795) 2730795..2731298 + 504 WP_031787686.1 PH domain-containing protein -
LK336_RS13130 (2731302) 2731302..2731661 + 360 WP_031787685.1 holo-ACP synthase -
LK336_RS13135 (2731731) 2731731..2732879 + 1149 WP_001281137.1 alanine racemase -
LK336_RS13140 (2732964) 2732964..2733134 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LK336_RS13145 (2733131) 2733131..2733493 + 363 WP_000621178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LK336_RS13150 (2733840) 2733840..2734841 + 1002 WP_000390825.1 PP2C family protein-serine/threonine phosphatase -
LK336_RS13155 (2734958) 2734958..2735284 + 327 WP_001052491.1 anti-sigma factor antagonist -
LK336_RS13160 (2735286) 2735286..2735765 + 480 WP_001190826.1 anti-sigma B factor RsbW -
LK336_RS13165 (2735740) 2735740..2736510 + 771 WP_001041104.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.79 Da        Isoelectric Point: 10.2892

>T223937 WP_000621178.1 NZ_CP086572:2733131-2733493 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

>T223937 NZ_CP119404:c3977978-3977691 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGTATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT223937 WP_000948331.1 NZ_CP086572:2732964-2733134 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT223937 NZ_CP119404:c3977704-3977402 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References