Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2712843..2713357 Replicon chromosome
Accession NZ_CP086572
Organism Staphylococcus argenteus strain RIVM_M036020

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag LK336_RS13060 Protein ID WP_000233591.1
Coordinates 2713148..2713357 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LK336_RS13055 Protein ID WP_000138932.1
Coordinates 2712843..2713136 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK336_RS13035 (2708324) 2708324..2708965 + 642 WP_031787699.1 thiamine phosphate synthase -
LK336_RS13040 (2709051) 2709051..2709920 + 870 WP_000725805.1 membrane protein insertase YidC -
LK336_RS13045 (2710515) 2710515..2711162 - 648 WP_031787698.1 HD domain-containing protein -
LK336_RS13050 (2711191) 2711191..2712675 - 1485 WP_031787697.1 cardiolipin synthase -
LK336_RS13055 (2712843) 2712843..2713136 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LK336_RS13060 (2713148) 2713148..2713357 + 210 WP_000233591.1 heavy metal-associated domain-containing protein Toxin
LK336_RS13065 (2713486) 2713486..2713623 + 138 WP_000828355.1 Lmo0850 family protein -
LK336_RS13070 (2714052) 2714052..2715254 - 1203 WP_031787696.1 FtsW/RodA/SpoVE family cell cycle protein -
LK336_RS13075 (2715573) 2715573..2716643 + 1071 WP_031787695.1 D-alanine--D-alanine ligase -
LK336_RS13080 (2716658) 2716658..2718022 + 1365 WP_031787694.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T223936 WP_000233591.1 NZ_CP086572:2713148-2713357 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T223936 NZ_CP119404:c3677529-3677131 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT223936 WP_000138932.1 NZ_CP086572:2712843-2713136 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT223936 NZ_CP119404:c3677825-3677532 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References