Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1183522..1183999 Replicon chromosome
Accession NZ_CP086572
Organism Staphylococcus argenteus strain RIVM_M036020

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag LK336_RS05830 Protein ID WP_000172413.1
Coordinates 1183811..1183999 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag LK336_RS05825 Protein ID WP_000790107.1
Coordinates 1183522..1183782 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK336_RS05790 (1178904) 1178904..1179623 - 720 WP_047451209.1 type I 3-dehydroquinate dehydratase -
LK336_RS05795 (1179772) 1179772..1180194 + 423 WP_001007646.1 organic hydroperoxide resistance protein -
LK336_RS05800 (1180601) 1180601..1181092 + 492 WP_000695603.1 GNAT family N-acetyltransferase -
LK336_RS05805 (1181256) 1181256..1181873 + 618 WP_031788104.1 LysE family transporter -
LK336_RS05810 (1181940) 1181940..1182521 - 582 WP_031788103.1 histidine phosphatase family protein -
LK336_RS05815 (1182746) 1182746..1182982 + 237 WP_000368686.1 hypothetical protein -
LK336_RS05820 (1182979) 1182979..1183182 - 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
LK336_RS05825 (1183522) 1183522..1183782 + 261 WP_000790107.1 hypothetical protein Antitoxin
LK336_RS05830 (1183811) 1183811..1183999 + 189 WP_000172413.1 hypothetical protein Toxin
LK336_RS05835 (1184534) 1184534..1185103 + 570 WP_031788102.1 lipoprotein N-acylation protein LnsA -
LK336_RS05840 (1185192) 1185192..1185476 + 285 WP_031788101.1 hypothetical protein -
LK336_RS05845 (1185537) 1185537..1185749 + 213 WP_001007088.1 hypothetical protein -
LK336_RS05850 (1186362) 1186362..1186562 - 201 WP_001059082.1 cold-shock protein -
LK336_RS05855 (1186926) 1186926..1187594 - 669 WP_031788100.1 thermonuclease family protein -
LK336_RS05860 (1187937) 1187937..1188419 - 483 WP_031788350.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T223932 WP_000172413.1 NZ_CP086572:1183811-1183999 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T223932 NZ_CP119404:2639741-2639848 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT223932 WP_000790107.1 NZ_CP086572:1183522-1183782 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT223932 NZ_CP119404:c2639694-2639628 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References