22393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 1929008..1930355 Replicon chromosome
Accession NC_009784
Organism Vibrio campbellii ATCC BAA-1116

Toxin (Protein)


Gene name sanaT Uniprot ID A7N7V0
Locus tag VIBHAR_RS26240 Protein ID WP_012130176.1
Coordinates 1929008..1929949 (-) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A1B1NML2
Locus tag VIBHAR_RS26245 Protein ID WP_021018080.1
Coordinates 1929951..1930355 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VIBHAR_RS26225 1926352..1927113 - 762 WP_012130173.1 hypothetical protein -
VIBHAR_RS30135 1927179..1927346 - 168 Protein_1744 restriction endonuclease subunit S -
VIBHAR_RS26235 1927441..1928988 - 1548 WP_021018081.1 type I restriction-modification system subunit M -
VIBHAR_RS26240 1929008..1929949 - 942 WP_012130176.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
VIBHAR_RS26245 1929951..1930355 - 405 WP_021018080.1 hypothetical protein Antitoxin
VIBHAR_RS26250 1930544..1931137 - 594 WP_012130178.1 tyrosine-type recombinase/integrase -
VIBHAR_RS26255 1931417..1931659 - 243 WP_012130179.1 hypothetical protein -
VIBHAR_RS26265 1932241..1932693 + 453 WP_021018079.1 hypothetical protein -
VIBHAR_RS26270 1932711..1933355 + 645 WP_012130182.1 DUF4150 domain-containing protein -
VIBHAR_RS26275 1933352..1934272 - 921 WP_012130183.1 IS5 family transposase -
VIBHAR_RS26280 1934303..1935283 - 981 WP_021018078.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1918826..1977482 58656


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(32-300)

Antitoxin

Protein of unknown function DUF6088

(7-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 35743.17 Da        Isoelectric Point: 5.2980

>T22393 WP_012130176.1 NC_009784:c1929949-1929008 [Vibrio campbellii ATCC BAA-1116]
MNTLKQQFLEVSDALELGNPAIIEKDYWVVTLLAELAKVSPEHHQMVFSGGTALAKSNVKILRMSEDVDIKLIPNPAFDE
LSRAKKKTARKACVNEIEQALTQSGLFNVETRSVRDEYRYVEFELKYPQQFSQAPCLRPIIKLELIETIPLLDVESRSIQ
SLVAELYQQPQEVSAFDCVSIHATLVEKIISMLRRTMSVKRNTERSDDVALVRHIYDVHCITKLAMPELNEIDGLFKAVL
AEDIARFGNQHAEFVANPKQELQLGLKELEENAIFRQRFQDFVTPMVFNTEPHDFDTCFASFKRIAASLIEKI

Download         Length: 942 bp

>T22393 NC_009784:c1929949-1929008 [Vibrio campbellii ATCC BAA-1116]
ATGAATACACTAAAACAACAATTCCTTGAGGTTTCCGATGCGCTTGAGCTCGGAAACCCAGCCATCATTGAAAAAGATTA
CTGGGTCGTGACTTTACTGGCTGAGCTAGCGAAAGTTTCTCCTGAGCATCATCAAATGGTGTTTTCTGGCGGCACTGCGT
TGGCGAAATCAAACGTTAAAATTCTAAGAATGTCGGAAGATGTGGATATAAAACTCATCCCCAACCCAGCATTTGATGAA
CTGAGTCGAGCGAAAAAGAAAACCGCGAGAAAGGCATGTGTTAACGAGATTGAACAGGCACTCACCCAGTCAGGGCTATT
TAACGTTGAAACGCGTTCTGTGCGAGATGAGTACCGCTACGTCGAGTTTGAACTTAAATACCCGCAGCAGTTTAGTCAAG
CGCCCTGCCTGCGCCCCATCATCAAGTTAGAGTTAATCGAAACCATTCCATTACTGGATGTGGAGTCGCGCAGCATTCAA
TCTCTGGTAGCAGAGTTGTACCAACAACCACAAGAAGTGAGTGCATTTGATTGCGTCTCTATCCATGCCACATTGGTTGA
AAAAATTATTTCAATGCTGCGCCGTACCATGTCGGTAAAACGCAATACGGAGCGAAGCGATGATGTTGCTTTAGTTCGCC
ATATTTACGATGTTCACTGCATAACAAAGCTCGCAATGCCAGAACTCAACGAGATAGATGGCCTATTCAAAGCGGTATTG
GCAGAAGATATTGCCCGCTTTGGCAATCAACATGCCGAGTTTGTTGCCAACCCCAAACAAGAGCTACAACTTGGCCTTAA
AGAGCTTGAGGAAAATGCAATATTCCGCCAACGATTTCAGGACTTCGTCACGCCAATGGTGTTTAACACCGAACCCCATG
ATTTTGATACCTGCTTTGCCTCATTTAAACGCATTGCAGCATCGCTAATTGAAAAAATTTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15200.53 Da        Isoelectric Point: 10.5319

>AT22393 WP_021018080.1 NC_009784:c1930355-1929951 [Vibrio campbellii ATCC BAA-1116]
MTAADRIYQKIKRSRRYVFERKDFDGFASYDQIGRALRQLVQQGELMKLGYGLYTKARINSLTGKPMPTNPGGTDALMRE
ILKMKGVDFEMDSLSLQSLSGTSTQIPSSIQYSWDPKQFNRKLVVGSRVLNLPS

Download         Length: 405 bp

>AT22393 NC_009784:c1930355-1929951 [Vibrio campbellii ATCC BAA-1116]
ATGACAGCAGCAGACCGCATTTATCAAAAGATAAAGCGTTCAAGACGTTATGTATTTGAACGCAAAGACTTTGATGGATT
TGCAAGTTACGACCAAATAGGTCGGGCCCTGAGGCAGCTTGTGCAGCAAGGTGAGTTAATGAAGCTTGGCTATGGCTTGT
ATACCAAAGCAAGAATCAATAGCCTCACTGGCAAGCCCATGCCGACTAATCCGGGAGGGACCGATGCCCTTATGCGAGAA
ATTCTTAAAATGAAAGGCGTTGATTTTGAGATGGATAGTCTATCGCTGCAAAGTCTTTCAGGCACGAGTACCCAAATTCC
ATCTTCTATTCAGTATTCATGGGACCCAAAACAGTTTAATCGCAAACTGGTGGTCGGTAGCCGTGTGCTGAACTTACCAA
GTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A7N7V0

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1NML2

References