Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2692192..2692721 Replicon chromosome
Accession NZ_CP086570
Organism Staphylococcus argenteus strain RIVM_M020832

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U7JQG1
Locus tag LK341_RS12835 Protein ID WP_000621178.1
Coordinates 2692359..2692721 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LK341_RS12830 Protein ID WP_000948331.1
Coordinates 2692192..2692362 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK341_RS12805 (2687981) 2687981..2688460 + 480 WP_031787688.1 PH domain-containing protein -
LK341_RS12810 (2688453) 2688453..2690036 + 1584 WP_031787687.1 PH domain-containing protein -
LK341_RS12815 (2690023) 2690023..2690526 + 504 WP_031787686.1 PH domain-containing protein -
LK341_RS12820 (2690530) 2690530..2690889 + 360 WP_031787685.1 holo-ACP synthase -
LK341_RS12825 (2690959) 2690959..2692107 + 1149 WP_001281137.1 alanine racemase -
LK341_RS12830 (2692192) 2692192..2692362 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LK341_RS12835 (2692359) 2692359..2692721 + 363 WP_000621178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LK341_RS12840 (2693068) 2693068..2694069 + 1002 WP_000390825.1 PP2C family protein-serine/threonine phosphatase -
LK341_RS12845 (2694186) 2694186..2694512 + 327 WP_001052491.1 anti-sigma factor antagonist -
LK341_RS12850 (2694514) 2694514..2694993 + 480 WP_001190826.1 anti-sigma B factor RsbW -
LK341_RS12855 (2694968) 2694968..2695738 + 771 WP_001041104.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13502.79 Da        Isoelectric Point: 10.2892

>T223926 WP_000621178.1 NZ_CP086570:2692359-2692721 [Staphylococcus argenteus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDNKMKEVDNALMISLGLNTMAHQKN

Download         Length: 363 bp

>T223926 NZ_CP119404:694993-695289 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT223926 WP_000948331.1 NZ_CP086570:2692192-2692362 [Staphylococcus argenteus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT223926 NZ_CP119404:695291-695686 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References