Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2672071..2672585 Replicon chromosome
Accession NZ_CP086570
Organism Staphylococcus argenteus strain RIVM_M020832

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag LK341_RS12750 Protein ID WP_000233591.1
Coordinates 2672376..2672585 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LK341_RS12745 Protein ID WP_000138932.1
Coordinates 2672071..2672364 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK341_RS12725 (2667552) 2667552..2668193 + 642 WP_031787699.1 thiamine phosphate synthase -
LK341_RS12730 (2668279) 2668279..2669148 + 870 WP_000725805.1 membrane protein insertase YidC -
LK341_RS12735 (2669743) 2669743..2670390 - 648 WP_031787698.1 HD domain-containing protein -
LK341_RS12740 (2670419) 2670419..2671903 - 1485 WP_031787697.1 cardiolipin synthase -
LK341_RS12745 (2672071) 2672071..2672364 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LK341_RS12750 (2672376) 2672376..2672585 + 210 WP_000233591.1 heavy metal-associated domain-containing protein Toxin
LK341_RS12755 (2672714) 2672714..2672851 + 138 WP_000828355.1 Lmo0850 family protein -
LK341_RS12760 (2673280) 2673280..2674482 - 1203 WP_031787696.1 FtsW/RodA/SpoVE family cell cycle protein -
LK341_RS12765 (2674801) 2674801..2675871 + 1071 WP_031787695.1 D-alanine--D-alanine ligase -
LK341_RS12770 (2675886) 2675886..2677250 + 1365 WP_031787694.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T223925 WP_000233591.1 NZ_CP086570:2672376-2672585 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T223925 NZ_CP119404:630418-630732 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT223925 WP_000138932.1 NZ_CP086570:2672071-2672364 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT223925 NZ_CP119404:630729-631145 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References