Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1140102..1140579 Replicon chromosome
Accession NZ_CP086570
Organism Staphylococcus argenteus strain RIVM_M020832

Toxin (Protein)


Gene name TsaT Uniprot ID A0A7U7JTG2
Locus tag LK341_RS05505 Protein ID WP_000172413.1
Coordinates 1140391..1140579 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A7U7JTE3
Locus tag LK341_RS05500 Protein ID WP_000790107.1
Coordinates 1140102..1140362 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LK341_RS05465 (1135484) 1135484..1136203 - 720 WP_047451209.1 type I 3-dehydroquinate dehydratase -
LK341_RS05470 (1136352) 1136352..1136774 + 423 WP_001007646.1 organic hydroperoxide resistance protein -
LK341_RS05475 (1137181) 1137181..1137672 + 492 WP_000695603.1 GNAT family N-acetyltransferase -
LK341_RS05480 (1137836) 1137836..1138453 + 618 WP_031788104.1 LysE family transporter -
LK341_RS05485 (1138520) 1138520..1139101 - 582 WP_031788103.1 histidine phosphatase family protein -
LK341_RS05490 (1139326) 1139326..1139562 + 237 WP_000368686.1 hypothetical protein -
LK341_RS05495 (1139559) 1139559..1139762 - 204 WP_000145167.1 sterile alpha motif-like domain-containing protein -
LK341_RS05500 (1140102) 1140102..1140362 + 261 WP_000790107.1 hypothetical protein Antitoxin
LK341_RS05505 (1140391) 1140391..1140579 + 189 WP_000172413.1 hypothetical protein Toxin
LK341_RS05510 (1141114) 1141114..1141683 + 570 WP_031788102.1 lipoprotein N-acylation protein LnsA -
LK341_RS05515 (1141772) 1141772..1142056 + 285 WP_031788101.1 hypothetical protein -
LK341_RS05520 (1142117) 1142117..1142329 + 213 WP_001007088.1 hypothetical protein -
LK341_RS05525 (1142942) 1142942..1143142 - 201 WP_001059082.1 cold-shock protein -
LK341_RS05530 (1143506) 1143506..1144174 - 669 WP_031788100.1 thermonuclease family protein -
LK341_RS05535 (1144517) 1144517..1144999 - 483 WP_031788350.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.89 Da        Isoelectric Point: 9.9971

>T223921 WP_000172413.1 NZ_CP086570:1140391-1140579 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Download         Length: 189 bp

>T223921 NZ_CP119402:c4212630-4212457 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10089.30 Da        Isoelectric Point: 4.1927

>AT223921 WP_000790107.1 NZ_CP086570:1140102-1140362 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Download         Length: 261 bp

>AT223921 NZ_CP119402:c4212954-4212658 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JTG2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JTE3

References