Detailed information of TA system TA223920

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 117196..117983
• Replicon: chromosome
• Accession: NZ_CP086570
• Organism: Staphylococcus argenteus strain RIVM_M020832

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: A0A7U7PZK3
• Locus tag: LK341_RS00730
• Protein ID: WP_000031103.1
• Coordinates: 117828..117983 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: LK341_RS00725
• Protein ID: WP_031787929.1
• Coordinates: 117196..117795 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LK341_RS00705 (113112)	113112..114569	+	1458	WP_000649887.1	ABC transporter permease subunit	-
LK341_RS00710 (114562)	114562..115284	+	723	WP_031787931.1	amino acid ABC transporter ATP-binding protein	-
LK341_RS00715 (115435)	115435..116565	+	1131	WP_031787930.1	tRNA epoxyqueuosine(34) reductase QueG	-
LK341_RS00720 (116567)	116567..117037	+	471	WP_000181399.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
LK341_RS00725 (117196)	117196..117795	+	600	WP_031787929.1	glucosamine-6-phosphate isomerase	Antitoxin
LK341_RS00730 (117828)	117828..117983	+	156	WP_000031103.1	SAS053 family protein	Toxin
LK341_RS00735 (118449)	118449..118850	+	402	WP_000901017.1	hypothetical protein	-
LK341_RS00740 (119021)	119021..120406	+	1386	WP_031787928.1	class II fumarate hydratase	-
LK341_RS00745 (120700)	120700..121521	-	822	WP_000669386.1	RluA family pseudouridine synthase	-
LK341_RS00750 (121683)	121683..122795	+	1113	WP_031787927.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6019.42 Da
• Isoelectric Point: 4.1469

>T223920 WP_000031103.1 NZ_CP086570:117828-117983 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Nucleotide

• Length: 156 bp

>T223920 NZ_CP119402:c4008694-4008317 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22447.58 Da
• Isoelectric Point: 5.7220

>AT223920 WP_031787929.1 NZ_CP086570:117196-117795 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEHGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT223920 NZ_CP119402:c4009115-4008741 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACTCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A7U7PZK3