22392

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2615949..2616496 Replicon chromosome
Accession NC_009783
Organism Vibrio campbellii ATCC BAA-1116

Toxin (Protein)


Gene name relE Uniprot ID A0A240EQK2
Locus tag VIBHAR_RS12180 Protein ID WP_012128216.1
Coordinates 2615949..2616251 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A7MSI1
Locus tag VIBHAR_RS12185 Protein ID WP_012128217.1
Coordinates 2616239..2616496 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
VIBHAR_RS12155 2611874..2612455 + 582 WP_012128210.1 DUF2913 family protein -
VIBHAR_RS12160 2612847..2613134 - 288 WP_012128211.1 type II toxin-antitoxin system RelE/ParE family toxin -
VIBHAR_RS12165 2613131..2613412 - 282 WP_012128212.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
VIBHAR_RS12170 2613626..2614471 + 846 Protein_2325 IS4 family transposase -
VIBHAR_RS12175 2614582..2615590 + 1009 Protein_2326 IS110 family transposase -
VIBHAR_RS28600 2615795..2615911 - 117 WP_080514140.1 DUF3265 domain-containing protein -
VIBHAR_RS12180 2615949..2616251 - 303 WP_012128216.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
VIBHAR_RS12185 2616239..2616496 - 258 WP_012128217.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
VIBHAR_RS12190 2616669..2617822 + 1154 Protein_2330 IS110 family transposase -
VIBHAR_RS12195 2618324..2618509 + 186 Protein_2331 IS110 family transposase -
VIBHAR_RS12200 2618569..2619600 + 1032 WP_012128221.1 IS630 family transposase -
VIBHAR_RS12205 2619779..2620738 + 960 WP_012128222.1 thioredoxin-disulfide reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2613131..2631412 18281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11699.59 Da        Isoelectric Point: 5.1765

>T22392 WP_012128216.1 NC_009783:c2616251-2615949 [Vibrio campbellii ATCC BAA-1116]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDSDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T22392 NC_009783:c2616251-2615949 [Vibrio campbellii ATCC BAA-1116]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCAGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACAGTGACAAAGTG
TTTATTCTGTTTGTTATGCGTGCAGAGAGAGATTTACGTAAGTTCTTGTTGAGTAAGCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9548.06 Da        Isoelectric Point: 7.3177

>AT22392 WP_012128217.1 NC_009783:c2616496-2616239 [Vibrio campbellii ATCC BAA-1116]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALAGGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT22392 NC_009783:c2616496-2616239 [Vibrio campbellii ATCC BAA-1116]
ATGAAAGTAGAACTAGTTACATCACTCAAGCGTCAAGCAACTAAGATCCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGGCGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A240EQK2

Antitoxin

Source ID Structure
AlphaFold DB A7MSI1

References