Detailed information of TA system TA022391

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 2612847..2613412
• Replicon: chromosome
• Accession: NC_009783
• Organism: Vibrio campbellii ATCC BAA-1116

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A7MYG8
• Locus tag: VIBHAR_RS12160
• Protein ID: WP_012128211.1
• Coordinates: 2612847..2613134 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A7MYH0
• Locus tag: VIBHAR_RS12165
• Protein ID: WP_012128212.1
• Coordinates: 2613131..2613412 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
VIBHAR_RS30055	2608407..2608565	+	159	Protein_2318	IS110 family transposase	-
VIBHAR_RS12140	2608626..2609057	-	432	WP_012128204.1	GrpB family protein	-
VIBHAR_RS12145	2609339..2610537	+	1199	Protein_2320	IS4 family transposase	-
VIBHAR_RS30625	2610648..2611202	+	555	Protein_2321	IS110 family transposase	-
VIBHAR_RS12155	2611874..2612455	+	582	WP_012128210.1	DUF2913 family protein	-
VIBHAR_RS12160	2612847..2613134	-	288	WP_012128211.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
VIBHAR_RS12165	2613131..2613412	-	282	WP_012128212.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
VIBHAR_RS12170	2613626..2614471	+	846	Protein_2325	IS4 family transposase	-
VIBHAR_RS12175	2614582..2615590	+	1009	Protein_2326	IS110 family transposase	-
VIBHAR_RS28600	2615795..2615911	-	117	WP_080514140.1	DUF3265 domain-containing protein	-
VIBHAR_RS12180	2615949..2616251	-	303	WP_012128216.1	type II toxin-antitoxin system RelE/ParE family toxin	-
VIBHAR_RS12185	2616239..2616496	-	258	WP_012128217.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
VIBHAR_RS12190	2616669..2617822	+	1154	Protein_2330	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2609615..2609929	314

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10955.64 Da
• Isoelectric Point: 5.5379

>T22391 WP_012128211.1 NC_009783:c2613134-2612847 [Vibrio campbellii ATCC BAA-1116]
MKVVWSPLALQKLGDAAEFISLDNPVAAEHWVNEVFDKTDLLSSMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRSCRQILTESDV

Nucleotide

• Length: 288 bp

>T22391 NC_009783:c2613134-2612847 [Vibrio campbellii ATCC BAA-1116]
ATGAAAGTAGTTTGGTCACCATTAGCATTACAAAAGTTAGGAGATGCAGCCGAGTTTATTTCATTAGATAATCCAGTGGC
GGCAGAACACTGGGTCAATGAAGTCTTCGACAAAACAGACCTTCTCTCAAGTATGCCCGAGATGGGGCGAATGGTTCCTG
AGCTACCTCATACCAATTATCGCGAAATCTTGTTTGGTCACTATCGAATCATATATAGCCTCAGCCATGAAATTCGTGTT
CTTACGGTACGAAGTTGTCGTCAGATATTAACGGAAAGTGACGTGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10444.97 Da
• Isoelectric Point: 5.8719

>AT22391 WP_012128212.1 NC_009783:c2613412-2613131 [Vibrio campbellii ATCC BAA-1116]
MSRIHFDQDIQTLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGISN
EDARAQVLGRLKK

Nucleotide

• Length: 282 bp

>AT22391 NC_009783:c2613412-2613131 [Vibrio campbellii ATCC BAA-1116]
ATGAGTCGTATCCATTTTGATCAAGATATTCAGACTTTGTCTGAATTTCGTGCTGGCGTGACATCATTCATTAAACAGAT
TAACGAAACTCGCAGACCGCTAGTAATCACACAGCGCGGTAAAGGTGTTGCGGTTGTCCTTGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAGATCGAGTTACTAGAAGAAATGCGTACTGCTGAAGCTCAGTTAGCGTCAGGTTTAGGTATTTCCAAT
GAAGACGCTCGTGCTCAAGTGTTGGGACGTCTTAAGAAATGA

Structures

Toxin

• AlphaFold DB: A7MYG8

Antitoxin

• AlphaFold DB: A7MYH0