Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
| Location | 2005399..2006092 | Replicon | chromosome |
| Accession | NZ_CP086560 | ||
| Organism | Enterococcus faecalis strain E509 | ||
Toxin (Protein)
| Gene name | IrrE | Uniprot ID | S4BLV4 |
| Locus tag | LM510_RS09795 | Protein ID | WP_002378467.1 |
| Coordinates | 2005748..2006092 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | ImmA | Uniprot ID | - |
| Locus tag | LM510_RS09790 | Protein ID | WP_002364355.1 |
| Coordinates | 2005399..2005731 (+) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LM510_RS09745 (2000871) | 2000871..2001605 | - | 735 | WP_002378463.1 | ERF family protein | - |
| LM510_RS09750 (2001598) | 2001598..2001915 | - | 318 | WP_002357007.1 | hypothetical protein | - |
| LM510_RS09755 (2002135) | 2002135..2002689 | + | 555 | WP_002357006.1 | hypothetical protein | - |
| LM510_RS09760 (2003116) | 2003116..2003310 | - | 195 | WP_002378464.1 | hypothetical protein | - |
| LM510_RS09765 (2003347) | 2003347..2003556 | - | 210 | WP_002378465.1 | hypothetical protein | - |
| LM510_RS09770 (2003611) | 2003611..2003799 | + | 189 | WP_002357001.1 | YegP family protein | - |
| LM510_RS09775 (2003825) | 2003825..2004550 | - | 726 | WP_002378466.1 | phage regulatory protein | - |
| LM510_RS09780 (2004589) | 2004589..2004900 | - | 312 | WP_002381719.1 | hypothetical protein | - |
| LM510_RS09785 (2004911) | 2004911..2005087 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
| LM510_RS09790 (2005399) | 2005399..2005731 | + | 333 | WP_002364355.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LM510_RS09795 (2005748) | 2005748..2006092 | + | 345 | WP_002378467.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
| LM510_RS09800 (2006128) | 2006128..2006856 | + | 729 | WP_002378468.1 | potassium channel family protein | - |
| LM510_RS09805 (2006956) | 2006956..2008104 | + | 1149 | WP_002378469.1 | site-specific integrase | - |
| LM510_RS09810 (2008141) | 2008141..2008575 | - | 435 | Protein_1897 | competence type IV pilus minor pilin ComGD | - |
| LM510_RS09815 (2008572) | 2008572..2008847 | - | 276 | WP_002356991.1 | competence type IV pilus major pilin ComGC | - |
| LM510_RS09820 (2008847) | 2008847..2009893 | - | 1047 | WP_002369171.1 | competence type IV pilus assembly protein ComGB | - |
| LM510_RS09825 (2009850) | 2009850..2010818 | - | 969 | WP_002364362.1 | competence type IV pilus ATPase ComGA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1959672..2008548 | 48876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13712.62 Da Isoelectric Point: 5.5523
>T223858 WP_002378467.1 NZ_CP086560:2005748-2006092 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYIELYKIPSFRNKMEAEADY
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLN
Download Length: 345 bp
>T223858 NZ_CP119367:3549830-3550117 [Pseudomonas sp. CBSPGW29]
ATGACCTATAACCTTGAGTTTGATGCACGAGCGCTAAAGGAATGGCGCAAGCTTGGGGATACCGTACGTCAACAGCTCAA
GAAAAAGCTGGTTGAGATCCTGACCCATCCACGTATTGAAGCTAACCGGCTGCATGGTTTGCCCGACTGCTACAAAATCA
AGCTGCGTAGCAGCGGTTACCGGTTGGTCTATCAGGTGATTGATCAGGAGGTCATGGTATTTGTGGTGGCTGTCGATAAG
CGTGAGCGCGACGAGGTATATCGTAAAGCTACCGAGCGCTTGAGTTAG
ATGACCTATAACCTTGAGTTTGATGCACGAGCGCTAAAGGAATGGCGCAAGCTTGGGGATACCGTACGTCAACAGCTCAA
GAAAAAGCTGGTTGAGATCCTGACCCATCCACGTATTGAAGCTAACCGGCTGCATGGTTTGCCCGACTGCTACAAAATCA
AGCTGCGTAGCAGCGGTTACCGGTTGGTCTATCAGGTGATTGATCAGGAGGTCATGGTATTTGTGGTGGCTGTCGATAAG
CGTGAGCGCGACGAGGTATATCGTAAAGCTACCGAGCGCTTGAGTTAG
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT223858 WP_002364355.1 NZ_CP086560:2005399-2005731 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT223858 NZ_CP119367:3549601-3549840 [Pseudomonas sp. CBSPGW29]
ATGGCCTCTATAAACATCCGTATCGACGACGACCTTAAAGCTCGCGCTTATCACGAGCTGGAAAAGTTGGGTGTCACCCC
TTCCGAATTGATGCGCCAAGCCCTGCAATATGTGGCTGAGCGCGGGCAATTACCGTTCAAGCCTGTTCTGATGACCGAGG
ACGATGAAGCCTTGTTGGCTACAGTTCGGGAACGGCTGGCTGCTCCCCAGCGAGTGAAGGTCTCACTGGATGACCTATAA
ATGGCCTCTATAAACATCCGTATCGACGACGACCTTAAAGCTCGCGCTTATCACGAGCTGGAAAAGTTGGGTGTCACCCC
TTCCGAATTGATGCGCCAAGCCCTGCAATATGTGGCTGAGCGCGGGCAATTACCGTTCAAGCCTGTTCTGATGACCGAGG
ACGATGAAGCCTTGTTGGCTACAGTTCGGGAACGGCTGGCTGCTCCCCAGCGAGTGAAGGTCTCACTGGATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|