Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1650388..1651525 Replicon chromosome
Accession NZ_CP086560
Organism Enterococcus faecalis strain E509

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag LM510_RS07915 Protein ID WP_002401483.1
Coordinates 1650388..1651251 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag LM510_RS07920 Protein ID WP_000301765.1
Coordinates 1651253..1651525 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM510_RS07885 (1646186) 1646186..1646953 - 768 WP_002357481.1 ribonuclease HII -
LM510_RS07890 (1646955) 1646955..1647806 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
LM510_RS07895 (1648082) 1648082..1648513 - 432 Protein_1517 2-dehydropantoate 2-reductase -
LM510_RS07900 (1648569) 1648569..1649249 - 681 WP_010710189.1 IS6-like element IS1216 family transposase -
LM510_RS07905 (1649323) 1649323..1649610 - 288 Protein_1519 DnaJ domain-containing protein -
LM510_RS07910 (1649630) 1649630..1649947 - 318 WP_002333463.1 hypothetical protein -
LM510_RS07915 (1650388) 1650388..1651251 - 864 WP_002401483.1 zeta toxin family protein Toxin
LM510_RS07920 (1651253) 1651253..1651525 - 273 WP_000301765.1 antitoxin Antitoxin
LM510_RS07925 (1651542) 1651542..1651757 - 216 WP_002295735.1 peptide-binding protein -
LM510_RS07930 (1651856) 1651856..1652752 - 897 WP_002387620.1 ParA family protein -
LM510_RS07935 (1652855) 1652855..1653115 - 261 Protein_1525 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
LM510_RS07940 (1653285) 1653285..1654022 - 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
LM510_RS07945 (1654147) 1654147..1654242 - 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
LM510_RS07950 (1654311) 1654311..1654433 - 123 Protein_1528 peptide-binding protein -
LM510_RS07955 (1654553) 1654553..1656040 - 1488 WP_010712965.1 type IA DNA topoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') / cat - 1599521..1721689 122168
- inside IScluster/Tn erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') / cat - 1648569..1682655 34086


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T223856 WP_002401483.1 NZ_CP086560:c1651251-1650388 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

>T223856 NZ_CP119366:c6669976-6669725 [Pseudomonas sp. CBSPBW29]
GTGTCGAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAACAATCGGCTTTTACCTGGGCCGAACGGGTAACGCTGCT
GCGGCGACTGGGCTACACGCAAATCGAAGGCGCGGGTAGCCGAGTCAGGTTCGACATAGGCGACCCCAGTGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAAATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT223856 WP_000301765.1 NZ_CP086560:c1651525-1651253 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT223856 NZ_CP119366:c6669728-6669372 [Pseudomonas sp. CBSPBW29]
GTGAACAACCAGCTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTCTTCGGAAAGCT
GCTTTTCATCAAGGCCCTGGTCAGCTACGAGGGGAAAACCGTCGCCGAACTGGATACGGCCTTTTGCACCGCCGTGGACG
ACTACATCGAGACCTGCATGGCCCTTGGGCAAACACCGGAAAAGCCCTGCAAGGGCTCGTTCAACGTCCGTGTCGGCCAT
GACCTCCATTTGGCCGCCGCCCTCGCGGCGACCCGGCAAAAAGTCACGCTGAACGACCTCACACGGCAAGCGCTGAACGA
ATTCCTGCAACATCGCGGCGCACTCGTTGCCGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References