Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 1650388..1651525 | Replicon | chromosome |
| Accession | NZ_CP086560 | ||
| Organism | Enterococcus faecalis strain E509 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | LM510_RS07915 | Protein ID | WP_002401483.1 |
| Coordinates | 1650388..1651251 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | R2XCR7 |
| Locus tag | LM510_RS07920 | Protein ID | WP_000301765.1 |
| Coordinates | 1651253..1651525 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LM510_RS07885 (1646186) | 1646186..1646953 | - | 768 | WP_002357481.1 | ribonuclease HII | - |
| LM510_RS07890 (1646955) | 1646955..1647806 | - | 852 | WP_002357480.1 | ribosome biogenesis GTPase YlqF | - |
| LM510_RS07895 (1648082) | 1648082..1648513 | - | 432 | Protein_1517 | 2-dehydropantoate 2-reductase | - |
| LM510_RS07900 (1648569) | 1648569..1649249 | - | 681 | WP_010710189.1 | IS6-like element IS1216 family transposase | - |
| LM510_RS07905 (1649323) | 1649323..1649610 | - | 288 | Protein_1519 | DnaJ domain-containing protein | - |
| LM510_RS07910 (1649630) | 1649630..1649947 | - | 318 | WP_002333463.1 | hypothetical protein | - |
| LM510_RS07915 (1650388) | 1650388..1651251 | - | 864 | WP_002401483.1 | zeta toxin family protein | Toxin |
| LM510_RS07920 (1651253) | 1651253..1651525 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
| LM510_RS07925 (1651542) | 1651542..1651757 | - | 216 | WP_002295735.1 | peptide-binding protein | - |
| LM510_RS07930 (1651856) | 1651856..1652752 | - | 897 | WP_002387620.1 | ParA family protein | - |
| LM510_RS07935 (1652855) | 1652855..1653115 | - | 261 | Protein_1525 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| LM510_RS07940 (1653285) | 1653285..1654022 | - | 738 | WP_002292226.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| LM510_RS07945 (1654147) | 1654147..1654242 | - | 96 | WP_001809736.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| LM510_RS07950 (1654311) | 1654311..1654433 | - | 123 | Protein_1528 | peptide-binding protein | - |
| LM510_RS07955 (1654553) | 1654553..1656040 | - | 1488 | WP_010712965.1 | type IA DNA topoisomerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') / cat | - | 1599521..1721689 | 122168 | |
| - | inside | IScluster/Tn | erm(B) / ant(6)-Ia / lnu(B) / lsa(E) / aph(3')-III / aac(6')-aph(2'') / cat | - | 1648569..1682655 | 34086 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32486.06 Da Isoelectric Point: 6.9965
>T223856 WP_002401483.1 NZ_CP086560:c1651251-1650388 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
Download Length: 864 bp
>T223856 NZ_CP119366:c6669976-6669725 [Pseudomonas sp. CBSPBW29]
GTGTCGAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAACAATCGGCTTTTACCTGGGCCGAACGGGTAACGCTGCT
GCGGCGACTGGGCTACACGCAAATCGAAGGCGCGGGTAGCCGAGTCAGGTTCGACATAGGCGACCCCAGTGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAAATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA
GTGTCGAAAAATGAAAAGCTGCTGGCCAAACTGCTCAATGAACAATCGGCTTTTACCTGGGCCGAACGGGTAACGCTGCT
GCGGCGACTGGGCTACACGCAAATCGAAGGCGCGGGTAGCCGAGTCAGGTTCGACATAGGCGACCCCAGTGCAATGATCA
CCTTGCACAAGCCTCACCCCGGCAACGAACTGAAACACTACATTCGGCGCCAAATCATCGAACAATTGAAATCAGGAGAA
CTGATTCAGTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT223856 WP_000301765.1 NZ_CP086560:c1651525-1651253 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT223856 NZ_CP119366:c6669728-6669372 [Pseudomonas sp. CBSPBW29]
GTGAACAACCAGCTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTCTTCGGAAAGCT
GCTTTTCATCAAGGCCCTGGTCAGCTACGAGGGGAAAACCGTCGCCGAACTGGATACGGCCTTTTGCACCGCCGTGGACG
ACTACATCGAGACCTGCATGGCCCTTGGGCAAACACCGGAAAAGCCCTGCAAGGGCTCGTTCAACGTCCGTGTCGGCCAT
GACCTCCATTTGGCCGCCGCCCTCGCGGCGACCCGGCAAAAAGTCACGCTGAACGACCTCACACGGCAAGCGCTGAACGA
ATTCCTGCAACATCGCGGCGCACTCGTTGCCGGGTAA
GTGAACAACCAGCTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAAGACAACTGCCTCTTCGGAAAGCT
GCTTTTCATCAAGGCCCTGGTCAGCTACGAGGGGAAAACCGTCGCCGAACTGGATACGGCCTTTTGCACCGCCGTGGACG
ACTACATCGAGACCTGCATGGCCCTTGGGCAAACACCGGAAAAGCCCTGCAAGGGCTCGTTCAACGTCCGTGTCGGCCAT
GACCTCCATTTGGCCGCCGCCCTCGCGGCGACCCGGCAAAAAGTCACGCTGAACGACCTCACACGGCAAGCGCTGAACGA
ATTCCTGCAACATCGCGGCGCACTCGTTGCCGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|