Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 26517..27088 Replicon chromosome
Accession NZ_CP086560
Organism Enterococcus faecalis strain E509

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LM510_RS00115 Protein ID WP_002354774.1
Coordinates 26517..26858 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag LM510_RS00120 Protein ID WP_002354773.1
Coordinates 26858..27088 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM510_RS00110 (22532) 22532..26146 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
LM510_RS00115 (26517) 26517..26858 - 342 WP_002354774.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LM510_RS00120 (26858) 26858..27088 - 231 WP_002354773.1 hypothetical protein Antitoxin
LM510_RS00125 (27262) 27262..27477 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
LM510_RS00130 (27616) 27616..28608 + 993 WP_002378862.1 biotin--[acetyl-CoA-carboxylase] ligase -
LM510_RS00135 (28775) 28775..29413 - 639 WP_002378863.1 lytic polysaccharide monooxygenase -
LM510_RS00140 (30098) 30098..31714 + 1617 WP_002378864.1 phosphatase PAP2/LCP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13156.40 Da        Isoelectric Point: 9.3984

>T223845 WP_002354774.1 NZ_CP086560:c26858-26517 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETQGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

>T223845 NZ_CP119341:c2542747-2542640 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT223845 WP_002354773.1 NZ_CP086560:c27088-26858 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp

>AT223845 NZ_CP119341:2542563-2542623 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References