Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_19(antitoxin)
Location 1932830..1933523 Replicon chromosome
Accession NZ_CP086558
Organism Enterococcus faecalis strain E512

Toxin (Protein)


Gene name IrrE Uniprot ID -
Locus tag LM505_RS09535 Protein ID WP_002395798.1
Coordinates 1933179..1933523 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag LM505_RS09530 Protein ID WP_002364355.1
Coordinates 1932830..1933162 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM505_RS09490 (1928565) 1928565..1929302 - 738 WP_104670766.1 DnaD domain protein -
LM505_RS09495 (1929317) 1929317..1930132 - 816 WP_010783770.1 PD-(D/E)XK nuclease-like domain-containing protein -
LM505_RS09500 (1930095) 1930095..1931111 - 1017 WP_010820093.1 RecT family recombinase -
LM505_RS09505 (1931214) 1931214..1931438 - 225 WP_002391454.1 hypothetical protein -
LM505_RS09510 (1931435) 1931435..1931758 - 324 WP_010820095.1 hypothetical protein -
LM505_RS09515 (1931798) 1931798..1932013 - 216 WP_010783773.1 hypothetical protein -
LM505_RS09520 (1932020) 1932020..1932331 - 312 WP_002381719.1 hypothetical protein -
LM505_RS09525 (1932342) 1932342..1932518 - 177 WP_002364354.1 helix-turn-helix transcriptional regulator -
LM505_RS09530 (1932830) 1932830..1933162 + 333 WP_002364355.1 helix-turn-helix transcriptional regulator Antitoxin
LM505_RS09535 (1933179) 1933179..1933523 + 345 WP_002395798.1 ImmA/IrrE family metallo-endopeptidase Toxin
LM505_RS09540 (1933557) 1933557..1934291 + 735 WP_010820096.1 potassium channel family protein -
LM505_RS09545 (1934388) 1934388..1935536 + 1149 WP_229022057.1 site-specific integrase -
LM505_RS09550 (1935564) 1935564..1936007 - 444 WP_025189979.1 competence type IV pilus minor pilin ComGD -
LM505_RS09555 (1936004) 1936004..1936279 - 276 WP_002356991.1 competence type IV pilus major pilin ComGC -
LM505_RS09560 (1936279) 1936279..1937325 - 1047 WP_002356990.1 competence type IV pilus assembly protein ComGB -
LM505_RS09565 (1937282) 1937282..1938249 - 968 Protein_1863 competence type IV pilus ATPase ComGA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1885080..1956815 71735


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(22-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-63)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13718.69 Da        Isoelectric Point: 6.1363

>T223825 WP_002395798.1 NZ_CP086558:1933179-1933523 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK

Download         Length: 345 bp

>T223825 NZ_CP119338:c2150941-2150579 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12691.16 Da        Isoelectric Point: 4.6307

>AT223825 WP_002364355.1 NZ_CP086558:1932830-1933162 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK

Download         Length: 333 bp

>AT223825 NZ_CP119338:c2151108-2150938 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References