Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ImmA-IrrE/HTH_19(antitoxin) |
Location | 1932830..1933523 | Replicon | chromosome |
Accession | NZ_CP086558 | ||
Organism | Enterococcus faecalis strain E512 |
Toxin (Protein)
Gene name | IrrE | Uniprot ID | - |
Locus tag | LM505_RS09535 | Protein ID | WP_002395798.1 |
Coordinates | 1933179..1933523 (+) | Length | 115 a.a. |
Antitoxin (Protein)
Gene name | ImmA | Uniprot ID | - |
Locus tag | LM505_RS09530 | Protein ID | WP_002364355.1 |
Coordinates | 1932830..1933162 (+) | Length | 111 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LM505_RS09490 (1928565) | 1928565..1929302 | - | 738 | WP_104670766.1 | DnaD domain protein | - |
LM505_RS09495 (1929317) | 1929317..1930132 | - | 816 | WP_010783770.1 | PD-(D/E)XK nuclease-like domain-containing protein | - |
LM505_RS09500 (1930095) | 1930095..1931111 | - | 1017 | WP_010820093.1 | RecT family recombinase | - |
LM505_RS09505 (1931214) | 1931214..1931438 | - | 225 | WP_002391454.1 | hypothetical protein | - |
LM505_RS09510 (1931435) | 1931435..1931758 | - | 324 | WP_010820095.1 | hypothetical protein | - |
LM505_RS09515 (1931798) | 1931798..1932013 | - | 216 | WP_010783773.1 | hypothetical protein | - |
LM505_RS09520 (1932020) | 1932020..1932331 | - | 312 | WP_002381719.1 | hypothetical protein | - |
LM505_RS09525 (1932342) | 1932342..1932518 | - | 177 | WP_002364354.1 | helix-turn-helix transcriptional regulator | - |
LM505_RS09530 (1932830) | 1932830..1933162 | + | 333 | WP_002364355.1 | helix-turn-helix transcriptional regulator | Antitoxin |
LM505_RS09535 (1933179) | 1933179..1933523 | + | 345 | WP_002395798.1 | ImmA/IrrE family metallo-endopeptidase | Toxin |
LM505_RS09540 (1933557) | 1933557..1934291 | + | 735 | WP_010820096.1 | potassium channel family protein | - |
LM505_RS09545 (1934388) | 1934388..1935536 | + | 1149 | WP_229022057.1 | site-specific integrase | - |
LM505_RS09550 (1935564) | 1935564..1936007 | - | 444 | WP_025189979.1 | competence type IV pilus minor pilin ComGD | - |
LM505_RS09555 (1936004) | 1936004..1936279 | - | 276 | WP_002356991.1 | competence type IV pilus major pilin ComGC | - |
LM505_RS09560 (1936279) | 1936279..1937325 | - | 1047 | WP_002356990.1 | competence type IV pilus assembly protein ComGB | - |
LM505_RS09565 (1937282) | 1937282..1938249 | - | 968 | Protein_1863 | competence type IV pilus ATPase ComGA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1885080..1956815 | 71735 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 13718.69 Da Isoelectric Point: 6.1363
>T223825 WP_002395798.1 NZ_CP086558:1933179-1933523 [Enterococcus faecalis]
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK
MKSIKELVEEYEVELVFAPINKRACYEPVKRIIFVNQNLSIEEQEESIFHEFKHVVSHSDYMELYKIPSFRNKMEAEADH
HMFKCLIEKHDGQFNYSNVITHYNLKMGQETYLK
Download Length: 345 bp
>T223825 NZ_CP119338:c2150941-2150579 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 111 a.a. Molecular weight: 12691.16 Da Isoelectric Point: 4.6307
>AT223825 WP_002364355.1 NZ_CP086558:1932830-1933162 [Enterococcus faecalis]
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
MNLLERIKKLAKDRDVSIYQLEEEINIGRNTIYQWNKRTPSSDKLEAVANYFNVSVDYLLGRTENPNQAGAKPSDDLDEV
LDNVMSFDGEPLDDHDREVIRAYLKGRFGK
Download Length: 333 bp
>AT223825 NZ_CP119338:c2151108-2150938 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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