Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
| Location | 1576870..1578007 | Replicon | chromosome |
| Accession | NZ_CP086558 | ||
| Organism | Enterococcus faecalis strain E512 | ||
Toxin (Protein)
| Gene name | zeta | Uniprot ID | - |
| Locus tag | LM505_RS07665 | Protein ID | WP_002401483.1 |
| Coordinates | 1576870..1577733 (-) | Length | 288 a.a. |
Antitoxin (Protein)
| Gene name | epsilon | Uniprot ID | R2XCR7 |
| Locus tag | LM505_RS07670 | Protein ID | WP_000301765.1 |
| Coordinates | 1577735..1578007 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LM505_RS07635 (1572668) | 1572668..1573435 | - | 768 | WP_002357481.1 | ribonuclease HII | - |
| LM505_RS07640 (1573437) | 1573437..1574288 | - | 852 | WP_002357480.1 | ribosome biogenesis GTPase YlqF | - |
| LM505_RS07645 (1574564) | 1574564..1574995 | - | 432 | Protein_1479 | 2-dehydropantoate 2-reductase | - |
| LM505_RS07650 (1575051) | 1575051..1575731 | - | 681 | WP_010710189.1 | IS6-like element IS1216 family transposase | - |
| LM505_RS07655 (1575805) | 1575805..1576092 | - | 288 | Protein_1481 | DnaJ domain-containing protein | - |
| LM505_RS07660 (1576112) | 1576112..1576429 | - | 318 | WP_002333463.1 | hypothetical protein | - |
| LM505_RS07665 (1576870) | 1576870..1577733 | - | 864 | WP_002401483.1 | zeta toxin family protein | Toxin |
| LM505_RS07670 (1577735) | 1577735..1578007 | - | 273 | WP_000301765.1 | antitoxin | Antitoxin |
| LM505_RS07675 (1578024) | 1578024..1578239 | - | 216 | WP_002295735.1 | peptide-binding protein | - |
| LM505_RS07680 (1578338) | 1578338..1579234 | - | 897 | WP_002387620.1 | ParA family protein | - |
| LM505_RS07685 (1579337) | 1579337..1579597 | - | 261 | Protein_1487 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| LM505_RS07690 (1579767) | 1579767..1580463 | - | 697 | Protein_1488 | 23S ribosomal RNA methyltransferase Erm | - |
| LM505_RS07695 (1580658) | 1580658..1580705 | - | 48 | WP_229022136.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| LM505_RS07700 (1580788) | 1580788..1580910 | - | 123 | Protein_1490 | peptide-binding protein | - |
| LM505_RS07705 (1581118) | 1581118..1581252 | - | 135 | WP_229022137.1 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
| LM505_RS07710 (1581472) | 1581472..1582020 | - | 549 | Protein_1492 | DNA topoisomerase | - |
| LM505_RS15445 (1582110) | 1582110..1582220 | - | 111 | Protein_1493 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1575051..1575731 | 680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32486.06 Da Isoelectric Point: 6.9965
>T223823 WP_002401483.1 NZ_CP086558:c1577733-1576870 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL
Download Length: 864 bp
>T223823 NZ_CP119338:c938957-938769 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10721.25 Da Isoelectric Point: 6.4676
>AT223823 WP_000301765.1 NZ_CP086558:c1578007-1577735 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA
Download Length: 273 bp
>AT223823 NZ_CP119338:c939246-938986 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|