223823

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1576870..1578007 Replicon chromosome
Accession NZ_CP086558
Organism Enterococcus faecalis strain E512

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag LM505_RS07665 Protein ID WP_002401483.1
Coordinates 1576870..1577733 (-) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag LM505_RS07670 Protein ID WP_000301765.1
Coordinates 1577735..1578007 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM505_RS07635 (1572668) 1572668..1573435 - 768 WP_002357481.1 ribonuclease HII -
LM505_RS07640 (1573437) 1573437..1574288 - 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
LM505_RS07645 (1574564) 1574564..1574995 - 432 Protein_1479 2-dehydropantoate 2-reductase -
LM505_RS07650 (1575051) 1575051..1575731 - 681 WP_010710189.1 IS6-like element IS1216 family transposase -
LM505_RS07655 (1575805) 1575805..1576092 - 288 Protein_1481 DnaJ domain-containing protein -
LM505_RS07660 (1576112) 1576112..1576429 - 318 WP_002333463.1 hypothetical protein -
LM505_RS07665 (1576870) 1576870..1577733 - 864 WP_002401483.1 zeta toxin family protein Toxin
LM505_RS07670 (1577735) 1577735..1578007 - 273 WP_000301765.1 antitoxin Antitoxin
LM505_RS07675 (1578024) 1578024..1578239 - 216 WP_002295735.1 peptide-binding protein -
LM505_RS07680 (1578338) 1578338..1579234 - 897 WP_002387620.1 ParA family protein -
LM505_RS07685 (1579337) 1579337..1579597 - 261 Protein_1487 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
LM505_RS07690 (1579767) 1579767..1580463 - 697 Protein_1488 23S ribosomal RNA methyltransferase Erm -
LM505_RS07695 (1580658) 1580658..1580705 - 48 WP_229022136.1 23S rRNA methyltransferase attenuation leader peptide -
LM505_RS07700 (1580788) 1580788..1580910 - 123 Protein_1490 peptide-binding protein -
LM505_RS07705 (1581118) 1581118..1581252 - 135 WP_229022137.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
LM505_RS07710 (1581472) 1581472..1582020 - 549 Protein_1492 DNA topoisomerase -
LM505_RS15445 (1582110) 1582110..1582220 - 111 Protein_1493 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1575051..1575731 680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T223823 WP_002401483.1 NZ_CP086558:c1577733-1576870 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

>T223823 NZ_CP119338:c938957-938769 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT223823 WP_000301765.1 NZ_CP086558:c1578007-1577735 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp

>AT223823 NZ_CP119338:c939246-938986 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References