Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 2147093..2147631 Replicon chromosome
Accession NC_009782
Organism Staphylococcus aureus subsp. aureus Mu3

Toxin (Protein)


Gene name TscT Uniprot ID A0A0H3K0C1
Locus tag SAHV_RS10910 Protein ID WP_001078344.1
Coordinates 2147093..2147419 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID A0A0H3JSN0
Locus tag SAHV_RS10915 Protein ID WP_001058495.1
Coordinates 2147422..2147631 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHV_RS10885 2142306..2142647 - 342 WP_001190615.1 hypothetical protein -
SAHV_RS10890 2143108..2143749 - 642 WP_001047698.1 hypothetical protein -
SAHV_RS10895 2143746..2144126 - 381 WP_000356942.1 hypothetical protein -
SAHV_RS10900 2144436..2146145 - 1710 WP_000447473.1 DUF927 domain-containing protein -
SAHV_RS10905 2146159..2147028 - 870 WP_001002689.1 primase alpha helix C-terminal domain-containing protein -
SAHV_RS10910 2147093..2147419 - 327 WP_001078344.1 DUF1474 family protein Toxin
SAHV_RS10915 2147422..2147631 - 210 WP_001058495.1 hypothetical protein Antitoxin
SAHV_RS10920 2147624..2147770 - 147 WP_000784885.1 hypothetical protein -
SAHV_RS10925 2147767..2148084 - 318 WP_000481967.1 helix-turn-helix domain-containing protein -
SAHV_RS10930 2148089..2148307 - 219 WP_000153640.1 helix-turn-helix transcriptional regulator -
SAHV_RS10935 2148480..2149154 + 675 WP_000620857.1 helix-turn-helix transcriptional regulator -
SAHV_RS10940 2149168..2150340 + 1173 WP_000179343.1 site-specific integrase -
SAHV_RS10945 2150409..2152025 - 1617 WP_000240642.1 chaperonin GroEL -
SAHV_RS10950 2152101..2152385 - 285 WP_000917289.1 co-chaperone GroES -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / scn / sak / sea / hlb / sell / sec / tsst-1 / groEL 2082220..2152385 70165


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12968.26 Da        Isoelectric Point: 4.3050

>T22382 WP_001078344.1 NC_009782:c2147419-2147093 [Staphylococcus aureus subsp. aureus Mu3]
MNREIKDLFSDLKLLKDSFEDLKDSNGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T22382 NC_009782:c2147419-2147093 [Staphylococcus aureus subsp. aureus Mu3]
ATGAATCGGGAAATTAAAGATTTATTTAGCGATTTAAAGTTGTTGAAAGATAGTTTTGAGGATTTAAAGGATAGTAATGG
TTGGCATTTTGATGAGCTATATCCATATGAACCAAATCATGTCTTAAATAAAGATGAATTAATTGGAGAGGGATTTTCTT
ATCATGAGAGACGTATTCACAATAATCAAATGTTTGATTTATTCCATCTCTATATAGAGCAGTTCGATAATATTATCGAA
AAGTTTTATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGC
AGAGTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8206.22 Da        Isoelectric Point: 4.3718

>AT22382 WP_001058495.1 NC_009782:c2147631-2147422 [Staphylococcus aureus subsp. aureus Mu3]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT22382 NC_009782:c2147631-2147422 [Staphylococcus aureus subsp. aureus Mu3]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCGTGAATAATTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K0C1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3JSN0

References