223791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 19794..20259 Replicon plasmid pEc-042-T0_3
Accession NZ_CP086547
Organism Escherichia coli strain Ec-042-T0

Toxin (Protein)


Gene name TsxA Uniprot ID A0A5Y6UAV0
Locus tag LNN55_RS23350 Protein ID WP_001230708.1
Coordinates 19794..20045 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag LNN55_RS23355 Protein ID WP_000801440.1
Coordinates 20032..20259 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN55_RS23330 (LNN55_23325) 17314..17649 + 336 WP_001147119.1 type II toxin-antitoxin system RelE/ParE family toxin -
LNN55_RS23335 (LNN55_23330) 17646..17996 + 351 WP_000127483.1 hypothetical protein -
LNN55_RS23340 (LNN55_23335) 18635..19150 + 516 WP_001025396.1 J domain-containing protein -
LNN55_RS23345 (LNN55_23340) 19255..19797 + 543 WP_001083908.1 hypothetical protein -
LNN55_RS23350 (LNN55_23345) 19794..20045 + 252 WP_001230708.1 hypothetical protein Toxin
LNN55_RS23355 (LNN55_23350) 20032..20259 + 228 WP_000801440.1 hypothetical protein Antitoxin
LNN55_RS23360 (LNN55_23355) 20651..20950 + 300 WP_000650313.1 hypothetical protein -
LNN55_RS23365 (LNN55_23360) 21042..21407 + 366 WP_000854262.1 hypothetical protein -
LNN55_RS23370 (LNN55_23365) 21682..21855 + 174 WP_071821486.1 type II toxin-antitoxin system HicB family antitoxin -
LNN55_RS23375 (LNN55_23370) 22218..22721 + 504 WP_000781818.1 DNA distortion polypeptide 1 -
LNN55_RS23380 (LNN55_23375) 22725..23954 + 1230 WP_058815700.1 DNA relaxase/nickase TaxC -
LNN55_RS23385 (LNN55_23380) 24031..24324 + 294 WP_000134733.1 sigma factor-like helix-turn-helix DNA-binding protein -
LNN55_RS23390 (LNN55_23385) 24321..24536 + 216 WP_000760375.1 EexN family lipoprotein -
LNN55_RS23395 (LNN55_23390) 24713..24889 + 177 WP_000660496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34058 34058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-67)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9750.19 Da        Isoelectric Point: 9.8104

>T223791 WP_001230708.1 NZ_CP086547:19794-20045 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLRKDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

>T223791 NZ_CP119298:c4476793-4476038 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT223791 WP_000801440.1 NZ_CP086547:20032-20259 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp

>AT223791 NZ_CP119298:c4477296-4476928 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y6UAV0

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References