Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 898853..899330 Replicon chromosome
Accession NC_009782
Organism Staphylococcus aureus subsp. aureus Mu3

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAHV_RS04350 Protein ID WP_000052076.1
Coordinates 898853..899041 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAHV_RS04355 Protein ID WP_001059690.1
Coordinates 899070..899330 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAHV_RS04320 894847..895368 + 522 WP_000824482.1 hypothetical protein -
SAHV_RS04325 895709..896395 + 687 WP_000141557.1 thermonuclease family protein -
SAHV_RS04330 896752..896952 + 201 WP_001059082.1 cold-shock protein -
SAHV_RS04335 897444..897662 - 219 WP_000005886.1 hypothetical protein -
SAHV_RS04340 897724..898008 - 285 WP_001004399.1 hypothetical protein -
SAHV_RS04345 898096..898665 - 570 WP_001106654.1 hypothetical protein -
SAHV_RS04350 898853..899041 - 189 WP_000052076.1 hypothetical protein Toxin
SAHV_RS04355 899070..899330 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAHV_RS04360 899671..899874 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAHV_RS04365 899871..900107 - 237 WP_000349581.1 hypothetical protein -
SAHV_RS04370 900332..900913 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
SAHV_RS04375 900986..901603 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
SAHV_RS04380 901758..902252 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAHV_RS04385 902651..903073 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
SAHV_RS04390 903221..903937 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(7-67)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T22375 WP_000052076.1 NC_009782:c899041-898853 [Staphylococcus aureus subsp. aureus Mu3]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T22375 NC_009782:c899041-898853 [Staphylococcus aureus subsp. aureus Mu3]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT22375 WP_001059690.1 NC_009782:c899330-899070 [Staphylococcus aureus subsp. aureus Mu3]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT22375 NC_009782:c899330-899070 [Staphylococcus aureus subsp. aureus Mu3]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References