Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 115291..116894 Replicon plasmid pESA3
Accession NC_009780
Organism Cronobacter sakazakii ATCC BAA-894

Toxin (Protein)


Gene name hipA Uniprot ID A0A222ZDM8
Locus tag ESA_RS21150 Protein ID WP_041460783.1
Coordinates 115291..116610 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A222ZDV3
Locus tag ESA_RS21155 Protein ID WP_011999021.1
Coordinates 116613..116894 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESA_RS21140 110673..113204 - 2532 WP_011999018.1 malto-oligosyltrehalose synthase -
ESA_RS21145 113201..114985 - 1785 WP_011999019.1 malto-oligosyltrehalose trehalohydrolase -
ESA_RS21150 115291..116610 - 1320 WP_041460783.1 type II toxin-antitoxin system HipA family toxin Toxin
ESA_RS21155 116613..116894 - 282 WP_011999021.1 helix-turn-helix domain-containing protein Antitoxin
ESA_RS21160 117025..117909 - 885 WP_011999022.1 siderophore-interacting protein -
ESA_RS21165 117906..119117 - 1212 WP_011999023.1 MFS transporter -
ESA_RS21170 119253..121001 + 1749 WP_011999024.1 aerobactin synthase IucA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH / mgtB / iucA / iucB / iucC / iutA 1..131196 131196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49064.02 Da        Isoelectric Point: 6.8732

>T22373 WP_041460783.1 NC_009780:c116610-115291 [Cronobacter sakazakii ATCC BAA-894]
MRRTSRLALWMNGLPVGYWDKHNGEDRLTYLPEWIADPQGRPLSLSLPFTPGNQSYRGAQVRDYFDNLLPDSENIRRRLA
MRYRAQSLEPFDLLAELGRDCVGAIQLLPAGEAPEGLFTIRARPLSTVDIAAMLRHTAEAFPGQHGGEEELRLSIAGAQE
KTALLWHEDQWCLPEGNTPTTHIFKLPLGLVGNMQADMRTSIENEWLCAQLLAAWDIPVARTQMAQFEEQKVLIVERFDR
RLSGDGRWWLRLPQEDMCQALGVSPLRKYQADGGPGIGDIMTVLSRSENAQADRANFFRAQIIFWILAATDGHAKNFSIA
HLPGNRYHLTPLYDVLSAWPVIGPGNNQIAWQKCKLAMAVRGSSNYYHLSQIRRRHWLRQGELAGLSAAQVNDMIDALTA
SAPAVIARVADALPVDFPASLADVIFNGMHQQCARLAAA

Download         Length: 1320 bp

>T22373 NC_009780:c116610-115291 [Cronobacter sakazakii ATCC BAA-894]
ATGCGCCGCACGTCGCGTTTAGCGCTCTGGATGAACGGCCTGCCGGTCGGTTACTGGGATAAACACAACGGCGAAGACCG
GCTGACCTATCTGCCGGAGTGGATTGCCGATCCGCAGGGCAGGCCGCTGTCGCTGTCGCTGCCGTTCACGCCCGGTAATC
AGTCCTACCGCGGCGCGCAGGTGCGCGATTACTTCGACAACCTGCTGCCGGACAGCGAAAACATCCGGCGGCGGCTGGCG
ATGCGCTACCGGGCGCAGAGCCTGGAGCCGTTCGATCTGCTGGCGGAGCTGGGGCGCGACTGCGTCGGCGCTATTCAGCT
GCTGCCCGCCGGTGAAGCGCCGGAAGGGCTCTTTACCATCCGTGCCCGTCCACTCTCCACAGTGGATATTGCCGCGATGC
TGCGCCACACCGCAGAGGCGTTCCCCGGCCAGCATGGCGGCGAAGAGGAGCTGCGGCTCTCCATTGCGGGCGCGCAGGAG
AAAACCGCGCTGCTGTGGCACGAAGACCAGTGGTGCCTGCCGGAGGGCAACACGCCCACCACGCATATTTTCAAACTGCC
GCTGGGGCTGGTGGGCAACATGCAGGCGGATATGCGCACCTCCATTGAAAACGAATGGCTCTGCGCGCAGCTACTGGCGG
CCTGGGATATTCCGGTCGCGCGCACGCAGATGGCGCAGTTCGAAGAGCAAAAAGTGCTGATTGTTGAGCGCTTCGACCGC
CGTCTGTCCGGTGATGGCCGGTGGTGGCTGCGTCTGCCGCAGGAGGATATGTGCCAGGCGCTGGGCGTTTCGCCGCTGCG
TAAATATCAGGCCGACGGCGGGCCGGGCATCGGTGATATCATGACGGTTCTGAGCCGTTCAGAAAACGCGCAGGCGGATC
GCGCGAATTTCTTCCGCGCGCAGATTATCTTCTGGATCCTCGCCGCGACCGACGGCCACGCCAAGAATTTCAGCATTGCG
CATCTGCCCGGCAACCGTTACCACCTGACGCCGCTTTACGACGTGCTCTCCGCCTGGCCGGTCATCGGGCCCGGTAATAA
CCAGATTGCGTGGCAGAAGTGCAAGCTGGCGATGGCGGTGCGCGGCAGCAGTAACTATTACCACCTGAGCCAGATCCGCC
GCCGTCACTGGCTGCGCCAGGGCGAGCTTGCCGGGCTGTCGGCGGCGCAGGTCAACGACATGATTGATGCGCTGACAGCC
AGCGCGCCTGCGGTGATCGCGCGCGTGGCCGACGCGCTCCCGGTGGATTTCCCCGCCTCTCTGGCCGACGTTATTTTTAA
CGGCATGCACCAGCAGTGCGCGCGCCTCGCGGCCGCATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10537.04 Da        Isoelectric Point: 9.8007

>AT22373 WP_011999021.1 NC_009780:c116894-116613 [Cronobacter sakazakii ATCC BAA-894]
MNTRYPLKTLSQLRPLLVGFRKKQGLTQKEVSARLGVTQQTYARLEANPETASIERLFRVFNVLGIEMTLCETQAAESDA
PARDDSPARREAW

Download         Length: 282 bp

>AT22373 NC_009780:c116894-116613 [Cronobacter sakazakii ATCC BAA-894]
ATGAACACCCGGTATCCACTGAAAACGCTCAGCCAGCTGCGCCCGCTGCTGGTGGGCTTTCGTAAAAAACAGGGGCTGAC
CCAGAAAGAAGTTTCGGCGCGGCTTGGCGTCACGCAGCAAACCTATGCGCGGCTGGAGGCGAACCCCGAAACGGCCAGCA
TTGAGCGCCTGTTCCGCGTCTTTAACGTGCTGGGCATTGAGATGACGCTGTGCGAAACGCAGGCGGCGGAGTCTGACGCG
CCCGCGCGTGACGATTCGCCTGCCCGTCGCGAGGCGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A222ZDM8

Antitoxin

Source ID Structure
AlphaFold DB A0A222ZDV3

References