Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3447200..3447818 Replicon chromosome
Accession NZ_CP086526
Organism Escherichia coli strain Ec-042-T20-MAC

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LNN58_RS16825 Protein ID WP_001291435.1
Coordinates 3447600..3447818 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LNN58_RS16820 Protein ID WP_000344800.1
Coordinates 3447200..3447574 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN58_RS16810 (3442289) 3442289..3443482 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LNN58_RS16815 (3443505) 3443505..3446654 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LNN58_RS16820 (3447200) 3447200..3447574 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LNN58_RS16825 (3447600) 3447600..3447818 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LNN58_RS16830 (3447990) 3447990..3448541 + 552 WP_000102568.1 maltose O-acetyltransferase -
LNN58_RS16835 (3448657) 3448657..3449127 + 471 WP_000136192.1 YlaC family protein -
LNN58_RS16840 (3449291) 3449291..3450841 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LNN58_RS16845 (3450883) 3450883..3451236 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LNN58_RS16855 (3451615) 3451615..3451926 + 312 WP_000409911.1 MGMT family protein -
LNN58_RS16860 (3451957) 3451957..3452529 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T223705 WP_001291435.1 NZ_CP086526:3447600-3447818 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T223705 NZ_CP119139:c2794-2516 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT223705 WP_000344800.1 NZ_CP086526:3447200-3447574 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT223705 NZ_CP119139:c2979-2794 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References