Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2762811..2763430 Replicon chromosome
Accession NC_009778
Organism Cronobacter sakazakii ATCC BAA-894

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S9UIC9
Locus tag ESA_RS12955 Protein ID WP_004386909.1
Coordinates 2763212..2763430 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q9CL77
Locus tag ESA_RS12950 Protein ID WP_004386908.1
Coordinates 2762811..2763185 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESA_RS12940 2757972..2759177 + 1206 WP_012125452.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ESA_RS12945 2759199..2762348 + 3150 WP_007848020.1 multidrug efflux RND transporter permease subunit -
ESA_RS12950 2762811..2763185 + 375 WP_004386908.1 Hha toxicity modulator TomB Antitoxin
ESA_RS12955 2763212..2763430 + 219 WP_004386909.1 hemolysin expression modulator Hha Toxin
ESA_RS12960 2763639..2764190 + 552 WP_004386910.1 maltose O-acetyltransferase -
ESA_RS12965 2764310..2764819 + 510 WP_007891920.1 YlaC family protein -
ESA_RS22000 2764848..2764988 - 141 WP_004386911.1 type B 50S ribosomal protein L36 -
ESA_RS12970 2764992..2765252 - 261 WP_004386912.1 type B 50S ribosomal protein L31 -
ESA_RS12975 2765392..2767293 - 1902 WP_014729414.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8598.02 Da        Isoelectric Point: 9.4828

>T22370 WP_004386909.1 NC_009778:2763212-2763430 [Cronobacter sakazakii ATCC BAA-894]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T22370 NC_009778:2763212-2763430 [Cronobacter sakazakii ATCC BAA-894]
ATGACGACCAAACCATTAACCAAAACCGATTATTTAATGCGACTGAGACGTTGTCAGACAATTGACACGCTTGAGCGCGT
TATTGAAAAAAATAAATATGAATTATCCGACAACGAACTGGCGGTATTTTATTCAGCGGCGGATCATCGTCTGGCTGAAC
TGACGATGAATAAGCTCTACGATAAAATTCCGACCGCCGTGTGGAAGTTCGTTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14343.05 Da        Isoelectric Point: 4.7168

>AT22370 WP_004386908.1 NC_009778:2762811-2763185 [Cronobacter sakazakii ATCC BAA-894]
MDEYSPKRHDIAQLKFLCESLYHDCLATLGENQHGWVNDPTSAVNLQLNDLIEHIASFGLNYKIKHEDDAALIEQLDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVNASKENPVSLSF

Download         Length: 375 bp

>AT22370 NC_009778:2762811-2763185 [Cronobacter sakazakii ATCC BAA-894]
ATGGACGAATACTCACCAAAACGGCATGATATAGCGCAGCTTAAATTTCTTTGCGAAAGCCTGTATCATGATTGCCTTGC
CACGCTCGGCGAAAACCAGCATGGCTGGGTTAACGACCCCACTTCTGCCGTTAACCTGCAACTCAACGACTTGATTGAGC
ATATTGCCAGCTTCGGCCTGAATTATAAAATTAAGCATGAAGATGACGCAGCTCTCATTGAGCAATTAGATGAATATCTG
GATGATACCTTTATGCTGTTCAGCAATTACGGTATCAATGCGCAAGATTTACAAAAATGGCGCAAGTCCGGAAACAGGCT
TTTCCGGTGTTTCGTAAACGCCAGCAAAGAAAACCCTGTAAGCTTGTCTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9UIC9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CL77

References