Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1369430..1370055 Replicon chromosome
Accession NZ_CP086526
Organism Escherichia coli strain Ec-042-T20-MAC

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LNN58_RS06715 Protein ID WP_000911330.1
Coordinates 1369657..1370055 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LNN58_RS06710 Protein ID WP_000450524.1
Coordinates 1369430..1369657 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN58_RS06685 (1365233) 1365233..1365703 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
LNN58_RS06690 (1365703) 1365703..1366275 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LNN58_RS06695 (1366421) 1366421..1367299 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LNN58_RS06700 (1367316) 1367316..1368350 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
LNN58_RS06705 (1368563) 1368563..1369276 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LNN58_RS06710 (1369430) 1369430..1369657 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LNN58_RS06715 (1369657) 1369657..1370055 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
LNN58_RS06720 (1370202) 1370202..1371065 + 864 WP_001267507.1 neutral zinc metallopeptidase -
LNN58_RS06725 (1371080) 1371080..1373095 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
LNN58_RS06730 (1373169) 1373169..1373867 + 699 WP_000679823.1 esterase -
LNN58_RS06735 (1373977) 1373977..1374177 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T223695 WP_000911330.1 NZ_CP086526:1369657-1370055 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T223695 NZ_CP119137:843824-844237 [Salmonella enterica subsp. enterica serovar Goldcoast]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGCCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT223695 WP_000450524.1 NZ_CP086526:1369430-1369657 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT223695 NZ_CP119137:843577-843843 [Salmonella enterica subsp. enterica serovar Goldcoast]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References