Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1369416..1370041 Replicon chromosome
Accession NZ_CP086520
Organism Escherichia coli strain Ec-042-T20-ESBL

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LNN45_RS06705 Protein ID WP_000911330.1
Coordinates 1369643..1370041 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag LNN45_RS06700 Protein ID WP_000450524.1
Coordinates 1369416..1369643 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN45_RS06675 (1365219) 1365219..1365689 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
LNN45_RS06680 (1365689) 1365689..1366261 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
LNN45_RS06685 (1366407) 1366407..1367285 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
LNN45_RS06690 (1367302) 1367302..1368336 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
LNN45_RS06695 (1368549) 1368549..1369262 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
LNN45_RS06700 (1369416) 1369416..1369643 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
LNN45_RS06705 (1369643) 1369643..1370041 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
LNN45_RS06710 (1370188) 1370188..1371051 + 864 WP_001267507.1 neutral zinc metallopeptidase -
LNN45_RS06715 (1371066) 1371066..1373081 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
LNN45_RS06720 (1373155) 1373155..1373853 + 699 WP_000679823.1 esterase -
LNN45_RS06725 (1373963) 1373963..1374163 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T223669 WP_000911330.1 NZ_CP086520:1369643-1370041 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T223669 NZ_CP119120:c3889855-3889448 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT223669 WP_000450524.1 NZ_CP086520:1369416-1369643 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT223669 NZ_CP119120:c3890102-3889836 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References