223660

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 9618..10119 Replicon plasmid pEc-050-T0_5
Accession NZ_CP086515
Organism Escherichia coli strain Ec-050-T0

Toxin (Protein)


Gene name TsxA Uniprot ID Q9F571
Locus tag LNN50_RS25595 Protein ID WP_000702246.1
Coordinates 9618..9878 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID -
Locus tag LNN50_RS25600 Protein ID WP_001132407.1
Coordinates 9868..10119 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN50_RS25550 (LNN50_25555) 4809..5093 - 285 WP_001162371.1 hypothetical protein -
LNN50_RS25555 (LNN50_25560) 5172..5837 - 666 WP_000532148.1 division plane positioning ATPase MipZ -
LNN50_RS25560 (LNN50_25565) 6435..6764 + 330 WP_000855118.1 hypothetical protein -
LNN50_RS25565 (LNN50_25570) 7345..7668 + 324 WP_000427402.1 hypothetical protein -
LNN50_RS25570 (LNN50_25575) 7710..7919 + 210 WP_000866037.1 hypothetical protein -
LNN50_RS25575 (LNN50_25580) 8017..8241 + 225 WP_000814384.1 hypothetical protein -
LNN50_RS25580 (LNN50_25585) 8292..8552 + 261 WP_000702246.1 hypothetical protein -
LNN50_RS25585 (LNN50_25590) 8542..8793 + 252 WP_001132407.1 transcriptional regulator -
LNN50_RS25590 (LNN50_25595) 9343..9567 + 225 WP_000814384.1 hypothetical protein -
LNN50_RS25595 (LNN50_25600) 9618..9878 + 261 WP_000702246.1 hypothetical protein Toxin
LNN50_RS25600 (LNN50_25605) 9868..10119 + 252 WP_001132407.1 transcriptional regulator Antitoxin
LNN50_RS25605 (LNN50_25610) 10669..10947 + 279 WP_000545937.1 hypothetical protein -
LNN50_RS25610 (LNN50_25615) 11367..11633 + 267 WP_000681608.1 type II toxin-antitoxin system HicB family antitoxin -
LNN50_RS25615 (LNN50_25620) 11740..12159 - 420 WP_242879860.1 hypothetical protein -
LNN50_RS25620 (LNN50_25625) 12456..12638 + 183 WP_000833470.1 type II toxin-antitoxin system HicA family toxin -
LNN50_RS25625 (LNN50_25630) 12663..13100 + 438 WP_000466318.1 type II toxin-antitoxin system HicB family antitoxin -
LNN50_RS25630 (LNN50_25635) 13231..13557 - 327 WP_000206697.1 hypothetical protein -
LNN50_RS25635 (LNN50_25640) 13577..14176 - 600 WP_000091422.1 hypothetical protein -
LNN50_RS25640 (LNN50_25645) 14223..14924 - 702 WP_000280995.1 StbB family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..61289 61289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(8-37)


Sequences


Toxin        


Download         Length: 87 a.a.        Molecular weight: 9891.42 Da        Isoelectric Point: 10.0665

>T223660 WP_000702246.1 NZ_CP086515:9618-9878 [Escherichia coli]
MKIRKGDRQYYLNKEGDTFHLVKRVKTFSKSATLGKTKATVKTVADLVFHEKAFDTIDFASDGLRENDKEIIFMMIQEMS
EGKNAK

Download         Length: 261 bp

>T223660 NZ_CP119120:c2045082-2044975 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9404.77 Da        Isoelectric Point: 9.8120

>AT223660 WP_001132407.1 NZ_CP086515:9868-10119 [Escherichia coli]
MPNENTPENIKRLRQKIGLTQKECAEIFSMSPRTWRRKEEPVGTASGTALTPVEFKFLLLLAGEHPDYVLCKRNKKNSDS
GSN

Download         Length: 252 bp

>AT223660 NZ_CP119120:2045129-2045195 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3E1XBA7


Antitoxin

Source ID Structure

References