Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 48489..49090 | Replicon | plasmid pEc-050-T0_3 |
| Accession | NZ_CP086513 | ||
| Organism | Escherichia coli strain Ec-050-T0 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LNN50_RS24760 | Protein ID | WP_168420618.1 |
| Coordinates | 48489..48869 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | LNN50_RS24765 | Protein ID | WP_001190712.1 |
| Coordinates | 48869..49090 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN50_RS24730 (LNN50_24735) | 44511..45539 | + | 1029 | WP_168420624.1 | tyrosine-type recombinase/integrase | - |
| LNN50_RS24735 (LNN50_24740) | 45613..45957 | + | 345 | WP_001191776.1 | hypothetical protein | - |
| LNN50_RS24740 (LNN50_24745) | 45954..46430 | + | 477 | WP_000861174.1 | hypothetical protein | - |
| LNN50_RS24745 (LNN50_24750) | 46427..46921 | + | 495 | WP_000640906.1 | dUTP diphosphatase | - |
| LNN50_RS24750 (LNN50_24755) | 46936..47598 | + | 663 | WP_168420622.1 | DUF2829 domain-containing protein | - |
| LNN50_RS24755 (LNN50_24760) | 47605..48405 | + | 801 | WP_168420620.1 | hypothetical protein | - |
| LNN50_RS24760 (LNN50_24765) | 48489..48869 | - | 381 | WP_168420618.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LNN50_RS24765 (LNN50_24770) | 48869..49090 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LNN50_RS24770 (LNN50_24775) | 49163..49552 | - | 390 | WP_168420616.1 | S24 family peptidase | - |
| LNN50_RS24775 (LNN50_24780) | 49676..49927 | - | 252 | WP_063074807.1 | DNA polymerase III subunit theta | - |
| LNN50_RS24780 (LNN50_24785) | 50242..51000 | - | 759 | WP_072756859.1 | hypothetical protein | - |
| LNN50_RS24785 (LNN50_24790) | 50997..51206 | - | 210 | WP_075660655.1 | hypothetical protein | - |
| LNN50_RS24790 (LNN50_24795) | 51286..51462 | - | 177 | WP_157902266.1 | hypothetical protein | - |
| LNN50_RS24795 (LNN50_24800) | 51462..51755 | - | 294 | WP_075660654.1 | hypothetical protein | - |
| LNN50_RS24800 (LNN50_24805) | 51768..52172 | - | 405 | WP_080077662.1 | hypothetical protein | - |
| LNN50_RS24805 (LNN50_24810) | 52165..52446 | - | 282 | WP_102218741.1 | ASCH domain-containing protein | - |
| LNN50_RS24810 (LNN50_24815) | 52439..52630 | - | 192 | WP_242806062.1 | DUF551 domain-containing protein | - |
| LNN50_RS24815 (LNN50_24820) | 53141..53266 | - | 126 | Protein_56 | DUF551 domain-containing protein | - |
| LNN50_RS24820 (LNN50_24825) | 53263..53472 | - | 210 | WP_000951710.1 | hypothetical protein | - |
| LNN50_RS24825 (LNN50_24830) | 53474..53668 | - | 195 | WP_000224731.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..90446 | 90446 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13605.50 Da Isoelectric Point: 5.6406
>T223655 WP_168420618.1 NZ_CP086513:c48869-48489 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPVLVELAVGAATGEIPVSSVAEKLRELFGSNI
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPVLVELAVGAATGEIPVSSVAEKLRELFGSNI
Download Length: 381 bp
>T223655 NZ_CP119113:c2244855-2244646 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT223655 WP_001190712.1 NZ_CP086513:c49090-48869 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT223655 NZ_CP119113:c2245160-2244867 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|