Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1077374..1077957 | Replicon | chromosome |
| Accession | NZ_CP086510 | ||
| Organism | Escherichia coli strain Ec-050-T0 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | S1EZP4 |
| Locus tag | LNN50_RS05230 | Protein ID | WP_000254738.1 |
| Coordinates | 1077622..1077957 (+) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | S1P3W5 |
| Locus tag | LNN50_RS05225 | Protein ID | WP_000581937.1 |
| Coordinates | 1077374..1077622 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN50_RS05215 (1073713) | 1073713..1075014 | + | 1302 | WP_000046812.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| LNN50_RS05220 (1075062) | 1075062..1077296 | + | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
| LNN50_RS05225 (1077374) | 1077374..1077622 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
| LNN50_RS05230 (1077622) | 1077622..1077957 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
| LNN50_RS05235 (1078028) | 1078028..1078819 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
| LNN50_RS05240 (1079047) | 1079047..1080684 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
| LNN50_RS05245 (1080772) | 1080772..1082070 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T223625 WP_000254738.1 NZ_CP086510:1077622-1077957 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T223625 NZ_CP119076:c2490116-2488803 [Klebsiella aerogenes]
ATGGCTGCACTCAGTACATGGATGAACGATGAGCTGGTCGGTACCCTGACCAAGCAGGCAAATGGCGCACATACCTTTCG
CTATGCCGAAGCCTGGCTGCTCAACCCGCGGGCGAGGCCGCTCTCTTTATCACTACCGCTGCAGTTCGGTAATATCACCT
CCGATGCGGTGTTCAATTATTTCGATAACCTACTACCGGATAGCGTGAAAGTCCGCGAGCGCATCGTAAAACGCTACCAG
GCGCGTTCAAAACAACCCTTTGACCTGTTGGCGGAAGTAGGGCGAGATAGTGTTGGTGCTGTCACCCTGCTGCCTGAGAG
CGAGCAGCCGATACTCGGCCATTTAGCCTGGGATTCTCTGGATGAAAAACGGCTACAAACGTTGCTCACCGCCTATCAGT
CCGATATTCCGTTAGGCATGATTGCGGGCCATGATGACTTCAGGATTTCAGTCGCTGGCGCCCAGGAGAAGACCGCACTA
TTAAAAATCGACGGGATTTGGTCGATACCCAAAGGTACAACGCCCACAACGCATATCATCAAATTGCCAATCGGCGAGAT
AAAACAACCGAACGCGACGTTGGATCTCCGCGAAAGCGTGGATAATGAGTTTTTATGTCTGACCCTGGCGAGGGTGTTGG
GTTTCAAGGTGCCAGACGCTGAAATAATACGTACGCCAGATATTCGGGCGCTTGCGGTTGCGCGTTTCGATCGCCGCTGG
GCGCGCGATAATACGGTGCTACTGCGGCTGCCGCAGGAAGATCTCTGCCAGACCTTCGGGTTGCCATCGTCGATGAAATA
TGAGTCTGACGGCGGTCCGGGGATCCATGAAGTCATGAATTTTCTGCTTGGCTCCAGCGAAGCACTAACAGACCGCTATG
ATTTTATGAAATTCAATGTGTTCCAGTGGCTAATTGGCGCCACAGACGGTCATGCAAAAAACTTTTCCATATTCCTGCAG
CCGGGTGGCAGTTATCGCTTAACGCCGTTTTACGACATCCTCTCTGCTTTCCCGGTATTAGGCGGCACGGGTCTGCATTT
ACGAGATCTGAAATTATCGATGAGCCTGAAAGCAAGCAAGGGACGGAAGGTGGACATCAATACGCTTTATCCACGGCATT
TCCTCGCGACAGCCAAAGAGGTGAACTTCCCACAAGATCAGATGCAGGAGATTCTGCGTTTCTTTGCCGAAAATATTCCA
TCCGCTCTTGAGACTGCACTGGCTCGTTTGCCACATGATTTCTCTCCTGCCGTTTATCGTTCGGTGACGACTCATACGTT
GAAACTGCATGCACGGCTGATGGCTTCGCTATAA
ATGGCTGCACTCAGTACATGGATGAACGATGAGCTGGTCGGTACCCTGACCAAGCAGGCAAATGGCGCACATACCTTTCG
CTATGCCGAAGCCTGGCTGCTCAACCCGCGGGCGAGGCCGCTCTCTTTATCACTACCGCTGCAGTTCGGTAATATCACCT
CCGATGCGGTGTTCAATTATTTCGATAACCTACTACCGGATAGCGTGAAAGTCCGCGAGCGCATCGTAAAACGCTACCAG
GCGCGTTCAAAACAACCCTTTGACCTGTTGGCGGAAGTAGGGCGAGATAGTGTTGGTGCTGTCACCCTGCTGCCTGAGAG
CGAGCAGCCGATACTCGGCCATTTAGCCTGGGATTCTCTGGATGAAAAACGGCTACAAACGTTGCTCACCGCCTATCAGT
CCGATATTCCGTTAGGCATGATTGCGGGCCATGATGACTTCAGGATTTCAGTCGCTGGCGCCCAGGAGAAGACCGCACTA
TTAAAAATCGACGGGATTTGGTCGATACCCAAAGGTACAACGCCCACAACGCATATCATCAAATTGCCAATCGGCGAGAT
AAAACAACCGAACGCGACGTTGGATCTCCGCGAAAGCGTGGATAATGAGTTTTTATGTCTGACCCTGGCGAGGGTGTTGG
GTTTCAAGGTGCCAGACGCTGAAATAATACGTACGCCAGATATTCGGGCGCTTGCGGTTGCGCGTTTCGATCGCCGCTGG
GCGCGCGATAATACGGTGCTACTGCGGCTGCCGCAGGAAGATCTCTGCCAGACCTTCGGGTTGCCATCGTCGATGAAATA
TGAGTCTGACGGCGGTCCGGGGATCCATGAAGTCATGAATTTTCTGCTTGGCTCCAGCGAAGCACTAACAGACCGCTATG
ATTTTATGAAATTCAATGTGTTCCAGTGGCTAATTGGCGCCACAGACGGTCATGCAAAAAACTTTTCCATATTCCTGCAG
CCGGGTGGCAGTTATCGCTTAACGCCGTTTTACGACATCCTCTCTGCTTTCCCGGTATTAGGCGGCACGGGTCTGCATTT
ACGAGATCTGAAATTATCGATGAGCCTGAAAGCAAGCAAGGGACGGAAGGTGGACATCAATACGCTTTATCCACGGCATT
TCCTCGCGACAGCCAAAGAGGTGAACTTCCCACAAGATCAGATGCAGGAGATTCTGCGTTTCTTTGCCGAAAATATTCCA
TCCGCTCTTGAGACTGCACTGGCTCGTTTGCCACATGATTTCTCTCCTGCCGTTTATCGTTCGGTGACGACTCATACGTT
GAAACTGCATGCACGGCTGATGGCTTCGCTATAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT223625 WP_000581937.1 NZ_CP086510:1077374-1077622 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT223625 NZ_CP119076:c2490373-2490116 [Klebsiella aerogenes]
ATGATTTATAGCCCCGTGCAATTGGCGAACCATCTCAAACTGGTTCGCCAGAAAAACCAGTGGACCCAAAGTGATTTAGC
TCGTCGCATTGGGATAAAGCAGGCGACTATCTCTAATTTTGAAAATCATCCCGAGAAGACAACGCTCGCCACCGTATTTA
AGATTTTACAATCGCTTGAGTTGGTCATGTCTTTGAGTGCCAAAGGTGAGTCAACCGCACCGGCTGCCGGGAACCCACAA
CAGGATCTGGAGTGGTAA
ATGATTTATAGCCCCGTGCAATTGGCGAACCATCTCAAACTGGTTCGCCAGAAAAACCAGTGGACCCAAAGTGATTTAGC
TCGTCGCATTGGGATAAAGCAGGCGACTATCTCTAATTTTGAAAATCATCCCGAGAAGACAACGCTCGCCACCGTATTTA
AGATTTTACAATCGCTTGAGTTGGTCATGTCTTTGAGTGCCAAAGGTGAGTCAACCGCACCGGCTGCCGGGAACCCACAA
CAGGATCTGGAGTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|