Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 796310..797142 | Replicon | chromosome |
| Accession | NZ_CP086510 | ||
| Organism | Escherichia coli strain Ec-050-T0 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | LNN50_RS03865 | Protein ID | WP_000854765.1 |
| Coordinates | 796310..796684 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | LNN50_RS03870 | Protein ID | WP_001295723.1 |
| Coordinates | 796774..797142 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN50_RS03830 (791388) | 791388..791987 | + | 600 | WP_001255034.1 | type II secretion system minor pseudopilin GspJ | - |
| LNN50_RS03835 (791990) | 791990..792967 | + | 978 | WP_000633209.1 | type II secretion system minor pseudopilin GspK | - |
| LNN50_RS03840 (792964) | 792964..794142 | + | 1179 | WP_000094991.1 | type II secretion system protein GspL | - |
| LNN50_RS03845 (794144) | 794144..794680 | + | 537 | WP_000942785.1 | GspM family type II secretion system protein YghD | - |
| LNN50_RS03850 (794961) | 794961..795803 | - | 843 | WP_022645115.1 | DUF4942 domain-containing protein | - |
| LNN50_RS03855 (795888) | 795888..796082 | - | 195 | WP_024181941.1 | DUF957 domain-containing protein | - |
| LNN50_RS03860 (796107) | 796107..796310 | - | 204 | WP_001398797.1 | DUF5983 family protein | - |
| LNN50_RS03865 (796310) | 796310..796684 | - | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| LNN50_RS03870 (796774) | 796774..797142 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LNN50_RS03875 (797305) | 797305..797526 | - | 222 | WP_000692341.1 | DUF987 domain-containing protein | - |
| LNN50_RS03880 (797589) | 797589..798065 | - | 477 | WP_001186774.1 | RadC family protein | - |
| LNN50_RS03885 (798081) | 798081..798560 | - | 480 | WP_057109541.1 | antirestriction protein | - |
| LNN50_RS03890 (798826) | 798826..799644 | - | 819 | WP_001175165.1 | DUF932 domain-containing protein | - |
| LNN50_RS03895 (799734) | 799734..799967 | - | 234 | WP_001278293.1 | DUF905 family protein | - |
| LNN50_RS03900 (799973) | 799973..800650 | - | 678 | WP_001097302.1 | hypothetical protein | - |
| LNN50_RS03905 (800798) | 800798..801478 | - | 681 | WP_001282921.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T223623 WP_000854765.1 NZ_CP086510:c796684-796310 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T223623 NZ_CP119076:835078-835488 [Klebsiella aerogenes]
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTTCTGCACGGGGTGGTGGCGGC
AATCGTGCTGCTGGTGCCCTGGCCGCTAAGCTACACCCCGATTTGGCTACTGCTGCTATCGTTGGTGGTGTTTGACTGTG
TGCGCAGCCAGAGGCGGATCCATGCCTGTCAGGGTGAAATTAAGCTGTTGATCGACTCTCGTTTGCGTTGGCAAAAAACG
GAATGGGATATTGTCGGTACGCCCTGGGTTATCAGTAGCGGTATGCTGCTGCGCCTGAAGCAGGCGGAAAGCGGCCGTAG
CCAGCATCTGTGGGTGGCGGCGGACAGTATGGATGCGGGAGAGTGGCGGGATTTGCGCCGGCTGGTGCAACAAAAGCCGG
CGCGCGATTAA
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTTCTGCACGGGGTGGTGGCGGC
AATCGTGCTGCTGGTGCCCTGGCCGCTAAGCTACACCCCGATTTGGCTACTGCTGCTATCGTTGGTGGTGTTTGACTGTG
TGCGCAGCCAGAGGCGGATCCATGCCTGTCAGGGTGAAATTAAGCTGTTGATCGACTCTCGTTTGCGTTGGCAAAAAACG
GAATGGGATATTGTCGGTACGCCCTGGGTTATCAGTAGCGGTATGCTGCTGCGCCTGAAGCAGGCGGAAAGCGGCCGTAG
CCAGCATCTGTGGGTGGCGGCGGACAGTATGGATGCGGGAGAGTGGCGGGATTTGCGCCGGCTGGTGCAACAAAAGCCGG
CGCGCGATTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT223623 WP_001295723.1 NZ_CP086510:c797142-796774 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT223623 NZ_CP119076:834831-835097 [Klebsiella aerogenes]
ATGGACATTAATAACAAAGCCCGCATCCACTGGGCATGCCGCCGTGGTATGCGTGAACTCGACATCTCCATCATGCCGTT
TTTCGAGTACGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTTATCCGTTTGCTGGAAAACGATGATCCAGACC
TGTTCAACTGGTTGATGAATCACGGCAAGCCAGCGGATGCGCAACTGCAACGGATGGTCAATTTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAATAACAAAGCCCGCATCCACTGGGCATGCCGCCGTGGTATGCGTGAACTCGACATCTCCATCATGCCGTT
TTTCGAGTACGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTTATCCGTTTGCTGGAAAACGATGATCCAGACC
TGTTCAACTGGTTGATGAATCACGGCAAGCCAGCGGATGCGCAACTGCAACGGATGGTCAATTTAATTCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|