Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsxAB/MqsA(antitoxin) |
| Location | 19133..19598 | Replicon | plasmid pEc-050-T5-MAC_6 |
| Accession | NZ_CP086506 | ||
| Organism | Escherichia coli strain Ec-050-T5-MAC | ||
Toxin (Protein)
| Gene name | TsxA | Uniprot ID | A0A5Y6UAV0 |
| Locus tag | LNN49_RS26045 | Protein ID | WP_001230708.1 |
| Coordinates | 19133..19384 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | TsxB | Uniprot ID | M7CCF8 |
| Locus tag | LNN49_RS26050 | Protein ID | WP_000801440.1 |
| Coordinates | 19371..19598 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN49_RS26025 (LNN49_26030) | 16653..16988 | + | 336 | WP_001147119.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LNN49_RS26030 (LNN49_26035) | 16985..17335 | + | 351 | WP_000127483.1 | hypothetical protein | - |
| LNN49_RS26035 (LNN49_26040) | 17974..18489 | + | 516 | WP_001025396.1 | J domain-containing protein | - |
| LNN49_RS26040 (LNN49_26045) | 18594..19136 | + | 543 | WP_001083908.1 | hypothetical protein | - |
| LNN49_RS26045 (LNN49_26050) | 19133..19384 | + | 252 | WP_001230708.1 | hypothetical protein | Toxin |
| LNN49_RS26050 (LNN49_26055) | 19371..19598 | + | 228 | WP_000801440.1 | hypothetical protein | Antitoxin |
| LNN49_RS26055 (LNN49_26060) | 19990..20289 | + | 300 | WP_000650313.1 | hypothetical protein | - |
| LNN49_RS26060 (LNN49_26065) | 20381..20746 | + | 366 | WP_000854262.1 | hypothetical protein | - |
| LNN49_RS26065 (LNN49_26070) | 21021..21194 | + | 174 | WP_071821486.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| LNN49_RS26070 (LNN49_26075) | 21557..22060 | + | 504 | WP_000781818.1 | DNA distortion polypeptide 1 | - |
| LNN49_RS26075 (LNN49_26080) | 22064..23293 | + | 1230 | WP_000539545.1 | DNA relaxase/nickase TaxC | - |
| LNN49_RS26080 (LNN49_26085) | 23370..23663 | + | 294 | WP_000134733.1 | sigma factor-like helix-turn-helix DNA-binding protein | - |
| LNN49_RS26085 (LNN49_26090) | 23660..23875 | + | 216 | WP_000760375.1 | EexN family lipoprotein | - |
| LNN49_RS26090 (LNN49_26095) | 24052..24228 | + | 177 | WP_000660496.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..33826 | 33826 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9750.19 Da Isoelectric Point: 9.8104
>T223619 WP_001230708.1 NZ_CP086506:19133-19384 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLRKDDETPVKNLIKEFMLN
ETR
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLRKDDETPVKNLIKEFMLN
ETR
Download Length: 252 bp
>T223619 NZ_CP119047:985763-985945 [Staphylococcus epidermidis]
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTTACTGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAACAGTAAATAG
ATGGCGAACAAAAAAGATTCCAAATTAAATTATCATGAAGAAGAAAACGCTATGGTTACTGACTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAGATTTCACAGGAAAATGATGAAGAAAAATTAAATCAATCTCATGATAACGAAGTTCGTT
CAGATTTTAAAAACAGTAAATAG
Antitoxin
Download Length: 76 a.a. Molecular weight: 8659.98 Da Isoelectric Point: 8.5105
>AT223619 WP_000801440.1 NZ_CP086506:19371-19598 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK
Download Length: 228 bp
>AT223619 NZ_CP119047:985140-985739 [Staphylococcus epidermidis]
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGTAAAGAACAAGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGTCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGCAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTAAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA
ATGGCAATGAATTTTAAAGTATTTGACAATAGTGAAAAAGTAGCAGAATATACTGCAGATATTCTACGTAAGCAGTTTAA
TAATAATCCAACTACTATTGCAGGATTTCATTTGAGTAAAGAACAAGCACCAGTGTTTGATGAACTTAAGAAAAATGTGG
AAAATCATGCAGTTGATTTCAGTCAAATAAATATTTTAGATTATGATGATAATCATTCTTATTATGAGGCTTTGGGTGTG
CCAACAGGTCAAATTTATTCCATTTCTTACGAAAATGATGCAATTGACTTTATCTCAGATAAGATTAAGACTAAAGAAAA
TAAAGGCAAACTGACAATGCAAGTCCTTACGATTGATGAAAATGGCAAACTTGACATTAGCGTTCGTCAAGGTTTGATGG
AAGCTAGAGAAATTTTCTTAGTTATTACTGGTGCTAATAAACGCGATATGGTAGAAAAACTTTACCGTGAAAATGGTAAG
ACTAGTTTTGAACCATCGGATTTAAAAGCACACCGTATGGTAAATGTTATCTTAGATAAAGAAGCGGCTGCAGGCTTACC
TGAAGACGTAAAAGAGTACTTCACTGCACGTTTTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y6UAV0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Y6U8W9 |