Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 411426..412089 Replicon chromosome
Accession NC_009778
Organism Cronobacter sakazakii ATCC BAA-894

Toxin (Protein)


Gene name cptA Uniprot ID A0A6L3S892
Locus tag ESA_RS01975 Protein ID WP_012123856.1
Coordinates 411673..412089 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3Q9CFW7
Locus tag ESA_RS01970 Protein ID WP_007870701.1
Coordinates 411426..411692 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESA_RS01945 406454..407887 - 1434 WP_012123851.1 6-phospho-beta-glucosidase -
ESA_RS01950 408039..408767 - 729 WP_012123852.1 MurR/RpiR family transcriptional regulator -
ESA_RS01955 408944..409258 + 315 WP_012123853.1 N(4)-acetylcytidine aminohydrolase -
ESA_RS01960 409401..410054 + 654 WP_007777939.1 hemolysin III family protein -
ESA_RS01965 410159..411148 - 990 WP_012123854.1 tRNA-modifying protein YgfZ -
ESA_RS01970 411426..411692 + 267 WP_007870701.1 FAD assembly factor SdhE Antitoxin
ESA_RS01975 411673..412089 + 417 WP_012123856.1 protein YgfX Toxin
ESA_RS01980 412103..412624 - 522 WP_004385676.1 flavodoxin FldB -
ESA_RS01985 412726..413622 + 897 WP_004385677.1 site-specific tyrosine recombinase XerD -
ESA_RS01990 413645..414364 + 720 WP_004385678.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
ESA_RS01995 414368..416101 + 1734 WP_041460381.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16467.47 Da        Isoelectric Point: 11.2099

>T22360 WP_012123856.1 NC_009778:411673-412089 [Cronobacter sakazakii ATCC BAA-894]
VVLWHSDLRVSWRSQWLSLLLHGAVAVIILLLPWPLRYLPVWMLLLSLVVFDCVRSQRRINAFQGEVSLTADYYLRWQGV
DWQICATPWMLRSGMMLRLRHPKTTRRHHVWLAADSMTEAEWRDLRRLLLQQPVGDKR

Download         Length: 417 bp

>T22360 NC_009778:411673-412089 [Cronobacter sakazakii ATCC BAA-894]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGCTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGTAGCCAGCGGCGTATCAATGCGTTCCAGGGCGAGGTCAGCCTGACGGCTGATTATTACCTTCGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGCTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCTAAAACGACACGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCAGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCG
TAGGCGACAAACGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.89 Da        Isoelectric Point: 4.8310

>AT22360 WP_007870701.1 NC_009778:411426-411692 [Cronobacter sakazakii ATCC BAA-894]
MDINNKARIHWACRRGMRELDISIMPFFEYDYDSLSDEDKRVFVRLLECDDPDLFNWLMNHGKPADAELARMVELIQQRN
QARGPVAL

Download         Length: 267 bp

>AT22360 NC_009778:411426-411692 [Cronobacter sakazakii ATCC BAA-894]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATGCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3S892

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9CFW7

References